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Polyethylene glycol plus ascorbic acid for bowel preparation in chronic kidney disease
The safety of polyethylene glycol plus ascorbic acid has not been fully investigated in patients with renal insufficiency. High-dose ascorbic acid could induce hyperoxaluria, thereby causing tubule-interstitial nephritis and renal failure. This study aims to evaluate the safety and efficacy of polye...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023895/ https://www.ncbi.nlm.nih.gov/pubmed/27603372 http://dx.doi.org/10.1097/MD.0000000000004755 |
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author | Lee, Jae Min Keum, Bora Yoo, In Kyung Kim, Seung Han Choi, Hyuk Soon Kim, Eun Sun Seo, Yeon Seok Jeen, Yoon Tae Chun, Hoon Jai Lee, Hong Sik Um, Soon Ho Kim, Chang Duck Kim, Myung Gyu Jo, Sang Kyung |
author_facet | Lee, Jae Min Keum, Bora Yoo, In Kyung Kim, Seung Han Choi, Hyuk Soon Kim, Eun Sun Seo, Yeon Seok Jeen, Yoon Tae Chun, Hoon Jai Lee, Hong Sik Um, Soon Ho Kim, Chang Duck Kim, Myung Gyu Jo, Sang Kyung |
author_sort | Lee, Jae Min |
collection | PubMed |
description | The safety of polyethylene glycol plus ascorbic acid has not been fully investigated in patients with renal insufficiency. High-dose ascorbic acid could induce hyperoxaluria, thereby causing tubule-interstitial nephritis and renal failure. This study aims to evaluate the safety and efficacy of polyethylene glycol plus ascorbic acid in patients with chronic kidney disease. We retrospectively reviewed prospectively collected data on colonoscopy in patients with impaired renal function. Patients were divided into 2 groups: 2 L polyethylene glycol plus ascorbic acid (n = 61) and 4 L polyethylene glycol (n = 80). The safety of the 2 groups was compared by assessing the differences in laboratory findings before and after bowel cleansing. The laboratory findings were not significantly different before and after the administration of 2 L polyethylene glycol plus ascorbic acid or 4 L polyethylene glycol. In both groups, the estimated glomerular filtration rate was not influenced by the administration of the bowel-cleansing agent. Patients’ reports on tolerance and acceptability were better in the 2 L polyethylene glycol plus ascorbic acid group than in the 4 L polyethylene glycol group. The 2 L polyethylene glycol plus ascorbic acid solution is a safe choice for bowel preparation before colonoscopy in patients with impaired renal function. |
format | Online Article Text |
id | pubmed-5023895 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-50238952016-09-26 Polyethylene glycol plus ascorbic acid for bowel preparation in chronic kidney disease Lee, Jae Min Keum, Bora Yoo, In Kyung Kim, Seung Han Choi, Hyuk Soon Kim, Eun Sun Seo, Yeon Seok Jeen, Yoon Tae Chun, Hoon Jai Lee, Hong Sik Um, Soon Ho Kim, Chang Duck Kim, Myung Gyu Jo, Sang Kyung Medicine (Baltimore) 4500 The safety of polyethylene glycol plus ascorbic acid has not been fully investigated in patients with renal insufficiency. High-dose ascorbic acid could induce hyperoxaluria, thereby causing tubule-interstitial nephritis and renal failure. This study aims to evaluate the safety and efficacy of polyethylene glycol plus ascorbic acid in patients with chronic kidney disease. We retrospectively reviewed prospectively collected data on colonoscopy in patients with impaired renal function. Patients were divided into 2 groups: 2 L polyethylene glycol plus ascorbic acid (n = 61) and 4 L polyethylene glycol (n = 80). The safety of the 2 groups was compared by assessing the differences in laboratory findings before and after bowel cleansing. The laboratory findings were not significantly different before and after the administration of 2 L polyethylene glycol plus ascorbic acid or 4 L polyethylene glycol. In both groups, the estimated glomerular filtration rate was not influenced by the administration of the bowel-cleansing agent. Patients’ reports on tolerance and acceptability were better in the 2 L polyethylene glycol plus ascorbic acid group than in the 4 L polyethylene glycol group. The 2 L polyethylene glycol plus ascorbic acid solution is a safe choice for bowel preparation before colonoscopy in patients with impaired renal function. Wolters Kluwer Health 2016-09-09 /pmc/articles/PMC5023895/ /pubmed/27603372 http://dx.doi.org/10.1097/MD.0000000000004755 Text en Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | 4500 Lee, Jae Min Keum, Bora Yoo, In Kyung Kim, Seung Han Choi, Hyuk Soon Kim, Eun Sun Seo, Yeon Seok Jeen, Yoon Tae Chun, Hoon Jai Lee, Hong Sik Um, Soon Ho Kim, Chang Duck Kim, Myung Gyu Jo, Sang Kyung Polyethylene glycol plus ascorbic acid for bowel preparation in chronic kidney disease |
title | Polyethylene glycol plus ascorbic acid for bowel preparation in chronic kidney disease |
title_full | Polyethylene glycol plus ascorbic acid for bowel preparation in chronic kidney disease |
title_fullStr | Polyethylene glycol plus ascorbic acid for bowel preparation in chronic kidney disease |
title_full_unstemmed | Polyethylene glycol plus ascorbic acid for bowel preparation in chronic kidney disease |
title_short | Polyethylene glycol plus ascorbic acid for bowel preparation in chronic kidney disease |
title_sort | polyethylene glycol plus ascorbic acid for bowel preparation in chronic kidney disease |
topic | 4500 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023895/ https://www.ncbi.nlm.nih.gov/pubmed/27603372 http://dx.doi.org/10.1097/MD.0000000000004755 |
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