ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a dismal survival rate. Persistent activation of pancreatic stellate cells (PSCs) can perturb the biomechanical homoeostasis of the tumour microenvironment to favour cancer cell invasion. Here we report that ATRA, an acti...

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Detalles Bibliográficos
Autores principales: Chronopoulos, Antonios, Robinson, Benjamin, Sarper, Muge, Cortes, Ernesto, Auernheimer, Vera, Lachowski, Dariusz, Attwood, Simon, García, Rebeca, Ghassemi, Saba, Fabry, Ben, del Río Hernández, Armando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023948/
https://www.ncbi.nlm.nih.gov/pubmed/27600527
http://dx.doi.org/10.1038/ncomms12630

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