Catalytic Thr or Ser Residue Modulates Structural Switches in 2-Cys Peroxiredoxin by Distinct Mechanisms

Typical 2-Cys Peroxiredoxins (2-Cys Prxs) reduce hydroperoxides with extraordinary rates due to an active site composed of a catalytic triad, containing a peroxidatic cysteine (C(P)), an Arg, and a Thr (or Ser). 2-Cys Prx are involved in processes such as cancer; neurodegeneration and host-pathogen...

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Detalles Bibliográficos
Autores principales: Tairum, Carlos A., Santos, Melina Cardoso, Breyer, Carlos A., Geyer, R. Ryan, Nieves, Cecilia J., Portillo-Ledesma, Stephanie, Ferrer-Sueta, Gerardo, Toledo, José Carlos, Toyama, Marcos H., Augusto, Ohara, Netto, Luis E. S., de Oliveira, Marcos A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024103/
https://www.ncbi.nlm.nih.gov/pubmed/27629822
http://dx.doi.org/10.1038/srep33133

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