DNA damage and Repair Modify DNA methylation and Chromatin Domain of the Targeted Locus: Mechanism of allele methylation polymorphism

We characterize the changes in chromatin structure, DNA methylation and transcription during and after homologous DNA repair (HR). We find that HR modifies the DNA methylation pattern of the repaired segment. HR also alters local histone H3 methylation as well chromatin structure by inducing DNA-chr...

Descripción completa

Detalles Bibliográficos
Autores principales: Russo, Giusi, Landi, Rosaria, Pezone, Antonio, Morano, Annalisa, Zuchegna, Candida, Romano, Antonella, Muller, Mark T., Gottesman, Max E., Porcellini, Antonio, Avvedimento, Enrico V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024116/
https://www.ncbi.nlm.nih.gov/pubmed/27629060
http://dx.doi.org/10.1038/srep33222

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024116/
https://www.ncbi.nlm.nih.gov/pubmed/27629060
http://dx.doi.org/10.1038/srep33222

Ejemplares similares