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DNA damage and Repair Modify DNA methylation and Chromatin Domain of the Targeted Locus: Mechanism of allele methylation polymorphism
We characterize the changes in chromatin structure, DNA methylation and transcription during and after homologous DNA repair (HR). We find that HR modifies the DNA methylation pattern of the repaired segment. HR also alters local histone H3 methylation as well chromatin structure by inducing DNA-chr...
Autores principales: | Russo, Giusi, Landi, Rosaria, Pezone, Antonio, Morano, Annalisa, Zuchegna, Candida, Romano, Antonella, Muller, Mark T., Gottesman, Max E., Porcellini, Antonio, Avvedimento, Enrico V. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024116/ https://www.ncbi.nlm.nih.gov/pubmed/27629060 http://dx.doi.org/10.1038/srep33222 |
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