Oncogenic Mutations Differentially Affect Bax Monomer, Dimer, and Oligomeric Pore Formation in the Membrane

Dysfunction of Bax, a pro-apoptotic regulator of cellular metabolism is implicated in neurodegenerative diseases and cancer. We have constructed the first atomistic models of the Bax oligomeric pore consisting with experimental residue-residue distances. The models are stable, capturing well double...

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Detalles Bibliográficos
Autores principales: Zhang, Mingzhen, Zheng, Jie, Nussinov, Ruth, Ma, Buyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024136/
https://www.ncbi.nlm.nih.gov/pubmed/27630059
http://dx.doi.org/10.1038/srep33340

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024136/
https://www.ncbi.nlm.nih.gov/pubmed/27630059
http://dx.doi.org/10.1038/srep33340

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