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siRNA capsulated brain-targeted nanoparticles specifically knock down OATP2B1 in mice: a mechanism for acute morphine tolerance suppression

Regulating main brain-uptake transporter of morphine may restrict its tolerance generation, then modify its antinociception. In this study, more than 2 fold higher intracellular uptake concentrations for morphine and morphine-6-glucuronide (M6G) were observed in stable expression cells, HEK293-hOATP...

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Detalles Bibliográficos
Autores principales:	Yang, Zi-Zhao, Li, Li, Wang, Lu, Xu, Ming-Cheng, An, Sai, Jiang, Chen, Gu, Jing-Kai, Wang, Zai-Jie Jim, Yu, Lu-Shan, Zeng, Su
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024137/ https://www.ncbi.nlm.nih.gov/pubmed/27629937 http://dx.doi.org/10.1038/srep33338

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