Cpf1 nucleases demonstrate robust activity to induce DNA modification by exploiting homology directed repair pathways in mammalian cells

BACKGROUND: Cpf1 nucleases have recently been repurposed for site-specific genome modification. Two members of the Cpf1 family, the AsCpf1 from Acidaminococcus sp. and the LbCpf1 from Lachnospiraceae bacterium were shown to induce higher indel frequencies than SpCas9 when examining four randomly-sel...

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Detalles Bibliográficos
Autores principales: Tóth, Eszter, Weinhardt, Nóra, Bencsura, Petra, Huszár, Krisztina, Kulcsár, Péter I., Tálas, András, Fodor, Elfrieda, Welker, Ervin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024423/
https://www.ncbi.nlm.nih.gov/pubmed/27630115
http://dx.doi.org/10.1186/s13062-016-0147-0

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