Protective effect of melatonin on soluble Aβ(1–42)-induced memory impairment, astrogliosis, and synaptic dysfunction via the Musashi1/Notch1/Hes1 signaling pathway in the rat hippocampus

BACKGROUND: Amyloid-beta (Aβ) plays a key role in Alzheimer’s disease (AD) pathogenesis, and soluble Aβ oligomers are more cytotoxic than Aβ fibrils. Recent evidence suggests that Notch signaling is affected by AD and other brain diseases. Melatonin exerts beneficial effects on many aspects of AD an...

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Detalles Bibliográficos
Autores principales: Zhang, Shuman, Wang, Pan, Ren, Lili, Hu, Chunli, Bi, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024520/
https://www.ncbi.nlm.nih.gov/pubmed/27630117
http://dx.doi.org/10.1186/s13195-016-0206-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024520/
https://www.ncbi.nlm.nih.gov/pubmed/27630117
http://dx.doi.org/10.1186/s13195-016-0206-x

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