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Oxidized Lipoprotein Uptake Through the CD36 Receptor Activates the NLRP3 Inflammasome in Human Retinal Pigment Epithelial Cells

PURPOSE: Accumulation of oxidized phospholipids/lipoproteins with age is suggested to contribute to the pathogenesis of AMD. We investigated the effect of oxidized LDL (ox-LDL) on human RPE cells. METHODS: Primary human fetal RPE (hf-RPE) and ARPE-19 cells were treated with different doses of LDL or...

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Detalles Bibliográficos
Autores principales:	Gnanaguru, Gopalan, Choi, Ariel R., Amarnani, Dhanesh, D'Amore, Patricia A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2016
Materias:	Retinal Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024668/ https://www.ncbi.nlm.nih.gov/pubmed/27607416 http://dx.doi.org/10.1167/iovs.15-18663

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