Precommitment low-level Neurog3 expression defines a long-lived mitotic endocrine-biased progenitor pool that drives production of endocrine-committed cells

The current model for endocrine cell specification in the pancreas invokes high-level production of the transcription factor Neurogenin 3 (Neurog3) in Sox9(+) bipotent epithelial cells as the trigger for endocrine commitment, cell cycle exit, and rapid delamination toward proto-islet clusters. This...

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Detalles Bibliográficos
Autores principales: Bechard, Matthew E., Bankaitis, Eric D., Hipkens, Susan B., Ustione, Alessandro, Piston, David W., Yang, Yu-Ping, Magnuson, Mark A., Wright, Christopher V.E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024683/
https://www.ncbi.nlm.nih.gov/pubmed/27585590
http://dx.doi.org/10.1101/gad.284729.116

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