Cargando…

Exploring the Inflammatory Metabolomic Profile to Predict Response to TNF-α Inhibitors in Rheumatoid Arthritis

In clinical practice, approximately one-third of patients with rheumatoid arthritis (RA) respond insufficiently to TNF-α inhibitors (TNFis). The aim of the study was to explore the use of a metabolomics to identify predictors for the outcome of TNFi therapy, and study the metabolomic fingerprint in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cuppen, Bart V. J., Fu, Junzeng, van Wietmarschen, Herman A., Harms, Amy C., Koval, Slavik, Marijnissen, Anne C. A., Peeters, Judith J. W., Bijlsma, Johannes W. J., Tekstra, Janneke, van Laar, Jacob M., Hankemeier, Thomas, Lafeber, Floris P. J. G., van der Greef, Jan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025050/ https://www.ncbi.nlm.nih.gov/pubmed/27631111 http://dx.doi.org/10.1371/journal.pone.0163087

Ejemplares similares

Differences between serum polar lipid profiles of male and female rheumatoid arthritis patients in response to glucocorticoid treatment
por: Fu, Junzeng, et al.
Publicado: (2016)

Metabolomics profiling of the free and total oxidised lipids in urine by LC-MS/MS: application in patients with rheumatoid arthritis
por: Fu, Junzeng, et al.
Publicado: (2016)

Utility of the HandScan in monitoring disease activity and prediction of clinical response in rheumatoid arthritis patients: an explorative study
por: Verhoeven, Maxime M A, et al.
Publicado: (2021)

Efficacy of Tocilizumab Monotherapy Versus Tocilizumab and Methotrexate Combination Therapy in the Prevention of Radiographic Progression in Rheumatoid Arthritis: An Analysis Using Individual Patient Data From Multiple Clinical Trials
por: Verhoeven, Maxime M. A., et al.
Publicado: (2022)

Can baseline serum microRNAs predict response to TNF-alpha inhibitors in rheumatoid arthritis?
por: Cuppen, Bart V. J., et al.
Publicado: (2016)

Polymorphisms in the multidrug-resistance 1 gene related to glucocorticoid response in rheumatoid arthritis treatment
por: Cuppen, Bart V. J., et al.
Publicado: (2017)

Baseline metabolic profiles of early rheumatoid arthritis patients achieving sustained drug-free remission after initiating treat-to-target tocilizumab, methotrexate, or the combination: insights from systems biology
por: Teitsma, Xavier M, et al.
Publicado: (2018)

Effectiveness of Remission Induction Strategies for Early Rheumatoid Arthritis: a Systematic Literature Review
por: Verhoeven, M. M. A., et al.
Publicado: (2019)

Collagen Induced Arthritis in DBA/1J Mice Associates with Oxylipin Changes in Plasma
por: He, Min, et al.
Publicado: (2015)

Tocilizumab as monotherapy or combination therapy for treating active rheumatoid arthritis: a meta-analysis of efficacy and safety reported in randomized controlled trials
por: Teitsma, Xavier M., et al.
Publicado: (2016)

Sub-Typing of Rheumatic Diseases Based on a Systems Diagnosis Questionnaire
por: van Wietmarschen, Herman A., et al.
Publicado: (2011)

Prediction Aided Tapering In rheumatoid arthritis patients treated with biOlogicals (PATIO): protocol for a randomized controlled trial
por: Messelink, Marianne A., et al.
Publicado: (2022)

Novel optical spectral transmission (OST)-guided versus conventionally disease activity-guided treatment: study protocol of a randomized clinical trial on guidance of a treat-to-target strategy for early rheumatoid arthritis
por: Besselink, N. J., et al.
Publicado: (2019)

Using real-world data to dynamically predict flares during tapering of biological DMARDs in rheumatoid arthritis: development, validation, and potential impact of prediction-aided decisions
por: van der Leeuw, Matthijs S., et al.
Publicado: (2022)

Development and Validation of Rheumatoid Arthritis Disease Activity Indices Including HandScan (Optical Spectral Transmission) Scores
por: Verhoeven, Maxime M. A., et al.
Publicado: (2022)

Concomitant prednisone may alleviate methotrexate side-effects in rheumatoid arthritis patients
por: van der Leeuw, Matthijs S., et al.
Publicado: (2023)

Tissue structure modification in knee osteoarthritis by use of joint distraction: an open 1-year pilot study
por: Intema, Femke, et al.
Publicado: (2011)

Effectiveness of TOcilizumab in comparison to Prednisone In Rheumatoid Arthritis patients with insufficient response to disease-modifying antirheumatic drugs (TOPIRA): study protocol for a pragmatic trial
por: van der Leeuw, Matthijs S., et al.
Publicado: (2020)

Characterization of Rheumatoid Arthritis Subtypes Using Symptom Profiles, Clinical Chemistry and Metabolomics Measurements
por: van Wietmarschen, Herman A., et al.
Publicado: (2012)

Effectiveness and safety over 3 years after the 2-year U-Act-Early trial of the strategies initiating tocilizumab and/or methotrexate
por: Verhoeven, Maxime M A, et al.
Publicado: (2020)

The multi-biomarker disease activity score tracks response to rituximab treatment in rheumatoid arthritis patients: a post hoc analysis of three cohort studies
por: Roodenrijs, Nadia M. T., et al.
Publicado: (2018)

Determining the Lowest Optimally Effective Methotrexate Dose for Individual RA Patients Using Their Dose Response Relation in a Tight Control Treatment Approach
por: Nair, Sandhya C., et al.
Publicado: (2016)

Identification of differential co-expressed gene networks in early rheumatoid arthritis achieving sustained drug-free remission after treatment with a tocilizumab-based or methotrexate-based strategy
por: Teitsma, Xavier M., et al.
Publicado: (2017)

Behҫet’s Disease, and the Role of TNF-α and TNF-α Blockers
por: van der Houwen, Tim, et al.
Publicado: (2020)

Differentiation of naive CD4(+ )T cells towards T helper 2 cells is not impaired in rheumatoid arthritis patients
por: van Roon, Joël AG, et al.
Publicado: (2003)

Integrative approaches to antimicrobial resistance
por: van Wietmarschen, Herman A.
Publicado: (2020)

A metabolomics study of Qiliqiangxin in a rat model of heart failure: a reverse pharmacology approach
por: Fu, Junzeng, et al.
Publicado: (2018)

Quantitative metabolomics based on gas chromatography mass spectrometry: status and perspectives
por: Koek, Maud M., et al.
Publicado: (2010)

Multi-biomarker disease activity score as a predictor of disease relapse in patients with rheumatoid arthritis stopping TNF inhibitor treatment
por: Ghiti Moghadam, Marjan, et al.
Publicado: (2018)

The multi-biomarker disease activity test for assessing response to treatment strategies using methotrexate with or without prednisone in the CAMERA-II trial
por: Jurgens, M. S., et al.
Publicado: (2020)

Safety of Anthroposophic Medicinal Products: An Analysis of Adverse Drug Reactions from German Pharmacovigilance Databases
por: Jong, Miek C., et al.
Publicado: (2021)

Development and application of a UHPLC–MS/MS metabolomics based comprehensive systemic and tissue-specific screening method for inflammatory, oxidative and nitrosative stress
por: Schoeman, Johannes C., et al.
Publicado: (2018)

Celecoxib: considerations regarding its potential disease-modifying properties in osteoarthritis
por: Zweers, Manon C, et al.
Publicado: (2011)

Differential direct effects of cyclo-oxygenase-1/2 inhibition on proteoglycan turnover of human osteoarthritic cartilage: an in vitro study
por: Mastbergen, Simon C, et al.
Publicado: (2006)

Interleukin-7-aggravated joint inflammation and tissue destruction in collagen-induced arthritis is associated with T-cell and B-cell activation
por: Hartgring, Sarita AY, et al.
Publicado: (2012)

COVID-19 related thrombi in ascending and descending thoracic aorta with peripheral embolization: a case report
por: Buikema, Jan W, et al.
Publicado: (2021)

Synovial T cell hyporesponsiveness to myeloid dendritic cells is reversed by preventing PD-1/PD-L1 interactions
por: Moret, Frederique M, et al.
Publicado: (2014)

Menstrual cycle rhythmicity: metabolic patterns in healthy women
por: Draper, C. F., et al.
Publicado: (2018)

Publisher Correction: Menstrual cycle rhythmicity: metabolic patterns in healthy women
por: Draper, C. F., et al.
Publicado: (2019)

A Personalized Approach to Biological Therapy Using Prediction of Clinical Response Based on MRP8/14 Serum Complex Levels in Rheumatoid Arthritis Patients
por: Nair, S. C., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_5kojfn1npdnqkqi60dvm3u8dq3