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Renal Denervation in a Real Life Setting: A Gradual Decrease in Home Blood Pressure

OBJECTIVES: To investigate the blood pressure dynamics after renal denervation through monthly home blood pressure measurements throughout the first 12 months. METHODS: A cohort of 70 patients performed highly standardized monthly home blood pressure monitoring during the first year after denervatio...

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Autores principales: Beeftink, Martine M. A., Spiering, Wilko, Bots, Michiel L., Verloop, Willemien L., De Jager, Rosa L., Sanders, Margreet F., Vonken, Evert-jan, Blankestijn, Peter J., Voskuil, Michiel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025101/
https://www.ncbi.nlm.nih.gov/pubmed/27631608
http://dx.doi.org/10.1371/journal.pone.0162251
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author Beeftink, Martine M. A.
Spiering, Wilko
Bots, Michiel L.
Verloop, Willemien L.
De Jager, Rosa L.
Sanders, Margreet F.
Vonken, Evert-jan
Blankestijn, Peter J.
Voskuil, Michiel
author_facet Beeftink, Martine M. A.
Spiering, Wilko
Bots, Michiel L.
Verloop, Willemien L.
De Jager, Rosa L.
Sanders, Margreet F.
Vonken, Evert-jan
Blankestijn, Peter J.
Voskuil, Michiel
author_sort Beeftink, Martine M. A.
collection PubMed
description OBJECTIVES: To investigate the blood pressure dynamics after renal denervation through monthly home blood pressure measurements throughout the first 12 months. METHODS: A cohort of 70 patients performed highly standardized monthly home blood pressure monitoring during the first year after denervation according to the European Society of Hypertension guidelines. At baseline and 12 months follow-up, office and ambulatory blood pressure as well as routine physical and laboratory assessment was performed. RESULTS: Home blood pressure decreased with a rate of 0.53 mmHg/month (95% CI 0.20 to 0.86) systolic and 0.26 mmHg/month (95% CI 0.08 to 0.44) diastolic throughout 12 months of follow-up, while the use of antihypertensive medication remained stable (+0.03 daily defined doses/month, 95% CI -0.01 to 0.08). On average, a 12 month reduction of 8.1 mmHg (95% CI 4.2 to 12.0) was achieved in home systolic blood pressure, 9.3 mmHg (95% CI -14.2 to -4.4) as measured by 24-hour ambulatory blood pressure monitoring and 15.9 mmHg (95% CI -23.8 to -7.9) on office measurements. CONCLUSION: Blood pressure reduction after renal denervation occurs as a gradual decrease that extends to at least one-year follow-up. Home monitoring seems a suitable alternative for ambulatory blood pressure monitoring after renal denervation.
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spelling pubmed-50251012016-09-27 Renal Denervation in a Real Life Setting: A Gradual Decrease in Home Blood Pressure Beeftink, Martine M. A. Spiering, Wilko Bots, Michiel L. Verloop, Willemien L. De Jager, Rosa L. Sanders, Margreet F. Vonken, Evert-jan Blankestijn, Peter J. Voskuil, Michiel PLoS One Research Article OBJECTIVES: To investigate the blood pressure dynamics after renal denervation through monthly home blood pressure measurements throughout the first 12 months. METHODS: A cohort of 70 patients performed highly standardized monthly home blood pressure monitoring during the first year after denervation according to the European Society of Hypertension guidelines. At baseline and 12 months follow-up, office and ambulatory blood pressure as well as routine physical and laboratory assessment was performed. RESULTS: Home blood pressure decreased with a rate of 0.53 mmHg/month (95% CI 0.20 to 0.86) systolic and 0.26 mmHg/month (95% CI 0.08 to 0.44) diastolic throughout 12 months of follow-up, while the use of antihypertensive medication remained stable (+0.03 daily defined doses/month, 95% CI -0.01 to 0.08). On average, a 12 month reduction of 8.1 mmHg (95% CI 4.2 to 12.0) was achieved in home systolic blood pressure, 9.3 mmHg (95% CI -14.2 to -4.4) as measured by 24-hour ambulatory blood pressure monitoring and 15.9 mmHg (95% CI -23.8 to -7.9) on office measurements. CONCLUSION: Blood pressure reduction after renal denervation occurs as a gradual decrease that extends to at least one-year follow-up. Home monitoring seems a suitable alternative for ambulatory blood pressure monitoring after renal denervation. Public Library of Science 2016-09-15 /pmc/articles/PMC5025101/ /pubmed/27631608 http://dx.doi.org/10.1371/journal.pone.0162251 Text en © 2016 Beeftink et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Beeftink, Martine M. A.
Spiering, Wilko
Bots, Michiel L.
Verloop, Willemien L.
De Jager, Rosa L.
Sanders, Margreet F.
Vonken, Evert-jan
Blankestijn, Peter J.
Voskuil, Michiel
Renal Denervation in a Real Life Setting: A Gradual Decrease in Home Blood Pressure
title Renal Denervation in a Real Life Setting: A Gradual Decrease in Home Blood Pressure
title_full Renal Denervation in a Real Life Setting: A Gradual Decrease in Home Blood Pressure
title_fullStr Renal Denervation in a Real Life Setting: A Gradual Decrease in Home Blood Pressure
title_full_unstemmed Renal Denervation in a Real Life Setting: A Gradual Decrease in Home Blood Pressure
title_short Renal Denervation in a Real Life Setting: A Gradual Decrease in Home Blood Pressure
title_sort renal denervation in a real life setting: a gradual decrease in home blood pressure
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025101/
https://www.ncbi.nlm.nih.gov/pubmed/27631608
http://dx.doi.org/10.1371/journal.pone.0162251
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