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Cosavirus, Salivirus and Bufavirus in Diarrheal Tunisian Infants

Three newly discovered viruses have been recently described in diarrheal patients: Cosavirus (CosV) and Salivirus (SalV), two picornaviruses, and Bufavirus (BuV), a parvovirus. The detection rate and the role of these viruses remain to be established in acute gastroenteritis (AGE) in diarrheal Tunis...

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Autores principales: Ayouni, Siwar, Estienney, Marie, Hammami, Sabeur, Neji Guediche, Mohamed, Pothier, Pierre, Aouni, Mahjoub, Belliot, Gael, de Rougemont, Alexis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025138/
https://www.ncbi.nlm.nih.gov/pubmed/27631733
http://dx.doi.org/10.1371/journal.pone.0162255
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author Ayouni, Siwar
Estienney, Marie
Hammami, Sabeur
Neji Guediche, Mohamed
Pothier, Pierre
Aouni, Mahjoub
Belliot, Gael
de Rougemont, Alexis
author_facet Ayouni, Siwar
Estienney, Marie
Hammami, Sabeur
Neji Guediche, Mohamed
Pothier, Pierre
Aouni, Mahjoub
Belliot, Gael
de Rougemont, Alexis
author_sort Ayouni, Siwar
collection PubMed
description Three newly discovered viruses have been recently described in diarrheal patients: Cosavirus (CosV) and Salivirus (SalV), two picornaviruses, and Bufavirus (BuV), a parvovirus. The detection rate and the role of these viruses remain to be established in acute gastroenteritis (AGE) in diarrheal Tunisian infants. From October 2010 through March 2012, stool samples were collected from 203 children <5 years-old suffering from AGE and attending the Children’s Hospital in Monastir, Tunisia. All samples were screened for CosV, SalV and BuV as well as for norovirus (NoV) and group A rotavirus (RVA) by molecular biology. Positive samples for the three screened viruses were also tested for astrovirus, sapovirus, adenovirus, and Aichi virus, then genotyped when technically feasible. During the study period, 11 (5.4%) samples were positive for one of the three investigated viruses: 2 (1.0%) CosV-A10, 7 (3.5%) SalV-A1 and 2 (1.0%) BuV-1, whereas 71 (35.0%) children were infected with NoV and 50 (24.6%) with RVA. No mixed infections involving the three viruses were found, but multiple infections with up to 4 classic enteric viruses were found in all cases. Although these viruses are suspected to be responsible for AGE in children, our data showed that this association was uncertain since all infected children also presented infections with several enteric viruses, suggesting here potential water-borne transmission. Therefore, further studies with large cohorts of healthy and diarrheal children will be needed to evaluate their clinical role in AGE.
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spelling pubmed-50251382016-09-27 Cosavirus, Salivirus and Bufavirus in Diarrheal Tunisian Infants Ayouni, Siwar Estienney, Marie Hammami, Sabeur Neji Guediche, Mohamed Pothier, Pierre Aouni, Mahjoub Belliot, Gael de Rougemont, Alexis PLoS One Research Article Three newly discovered viruses have been recently described in diarrheal patients: Cosavirus (CosV) and Salivirus (SalV), two picornaviruses, and Bufavirus (BuV), a parvovirus. The detection rate and the role of these viruses remain to be established in acute gastroenteritis (AGE) in diarrheal Tunisian infants. From October 2010 through March 2012, stool samples were collected from 203 children <5 years-old suffering from AGE and attending the Children’s Hospital in Monastir, Tunisia. All samples were screened for CosV, SalV and BuV as well as for norovirus (NoV) and group A rotavirus (RVA) by molecular biology. Positive samples for the three screened viruses were also tested for astrovirus, sapovirus, adenovirus, and Aichi virus, then genotyped when technically feasible. During the study period, 11 (5.4%) samples were positive for one of the three investigated viruses: 2 (1.0%) CosV-A10, 7 (3.5%) SalV-A1 and 2 (1.0%) BuV-1, whereas 71 (35.0%) children were infected with NoV and 50 (24.6%) with RVA. No mixed infections involving the three viruses were found, but multiple infections with up to 4 classic enteric viruses were found in all cases. Although these viruses are suspected to be responsible for AGE in children, our data showed that this association was uncertain since all infected children also presented infections with several enteric viruses, suggesting here potential water-borne transmission. Therefore, further studies with large cohorts of healthy and diarrheal children will be needed to evaluate their clinical role in AGE. Public Library of Science 2016-09-15 /pmc/articles/PMC5025138/ /pubmed/27631733 http://dx.doi.org/10.1371/journal.pone.0162255 Text en © 2016 Ayouni et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Ayouni, Siwar
Estienney, Marie
Hammami, Sabeur
Neji Guediche, Mohamed
Pothier, Pierre
Aouni, Mahjoub
Belliot, Gael
de Rougemont, Alexis
Cosavirus, Salivirus and Bufavirus in Diarrheal Tunisian Infants
title Cosavirus, Salivirus and Bufavirus in Diarrheal Tunisian Infants
title_full Cosavirus, Salivirus and Bufavirus in Diarrheal Tunisian Infants
title_fullStr Cosavirus, Salivirus and Bufavirus in Diarrheal Tunisian Infants
title_full_unstemmed Cosavirus, Salivirus and Bufavirus in Diarrheal Tunisian Infants
title_short Cosavirus, Salivirus and Bufavirus in Diarrheal Tunisian Infants
title_sort cosavirus, salivirus and bufavirus in diarrheal tunisian infants
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025138/
https://www.ncbi.nlm.nih.gov/pubmed/27631733
http://dx.doi.org/10.1371/journal.pone.0162255
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