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A Rational Engineering Strategy for Designing Protein A-Binding Camelid Single-Domain Antibodies
Staphylococcal protein A (SpA) and streptococcal protein G (SpG) affinity chromatography are the gold standards for purifying monoclonal antibodies (mAbs) in therapeutic applications. However, camelid V(H)H single-domain Abs (sdAbs or V(H)Hs) are not bound by SpG and only sporadically bound by SpA....
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025174/ https://www.ncbi.nlm.nih.gov/pubmed/27631624 http://dx.doi.org/10.1371/journal.pone.0163113 |