TOR and paradigm change: cell growth is controlled

This year marks the 25th anniversary of the discovery of target of rapamycin (TOR), a highly conserved kinase and central controller of cell growth. In this Retrospective, I briefly describe the discovery of TOR and the subsequent elucidation of its cellular role. I place particular emphasis on an a...

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Detalles Bibliográficos
Autor principal: Hall, Michael N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2016
Materias:
Retrospectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025266/
https://www.ncbi.nlm.nih.gov/pubmed/27634743
http://dx.doi.org/10.1091/mbc.E15-05-0311
Descripción
Sumario:This year marks the 25th anniversary of the discovery of target of rapamycin (TOR), a highly conserved kinase and central controller of cell growth. In this Retrospective, I briefly describe the discovery of TOR and the subsequent elucidation of its cellular role. I place particular emphasis on an article by Barbet et al. from 1996, the first suggesting that TOR controls cell growth in response to nutrients.

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