TOR and paradigm change: cell growth is controlled

This year marks the 25th anniversary of the discovery of target of rapamycin (TOR), a highly conserved kinase and central controller of cell growth. In this Retrospective, I briefly describe the discovery of TOR and the subsequent elucidation of its cellular role. I place particular emphasis on an a...

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Detalles Bibliográficos
Autor principal: Hall, Michael N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2016
Materias:
Retrospectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025266/
https://www.ncbi.nlm.nih.gov/pubmed/27634743
http://dx.doi.org/10.1091/mbc.E15-05-0311
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author Hall, Michael N.
author_facet Hall, Michael N.
author_sort Hall, Michael N.
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description This year marks the 25th anniversary of the discovery of target of rapamycin (TOR), a highly conserved kinase and central controller of cell growth. In this Retrospective, I briefly describe the discovery of TOR and the subsequent elucidation of its cellular role. I place particular emphasis on an article by Barbet et al. from 1996, the first suggesting that TOR controls cell growth in response to nutrients.
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spelling pubmed-50252662016-11-30 TOR and paradigm change: cell growth is controlled Hall, Michael N. Mol Biol Cell Retrospectives This year marks the 25th anniversary of the discovery of target of rapamycin (TOR), a highly conserved kinase and central controller of cell growth. In this Retrospective, I briefly describe the discovery of TOR and the subsequent elucidation of its cellular role. I place particular emphasis on an article by Barbet et al. from 1996, the first suggesting that TOR controls cell growth in response to nutrients. The American Society for Cell Biology 2016-09-15 /pmc/articles/PMC5025266/ /pubmed/27634743 http://dx.doi.org/10.1091/mbc.E15-05-0311 Text en © 2016 Hall. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.
spellingShingle Retrospectives
Hall, Michael N.
TOR and paradigm change: cell growth is controlled
title TOR and paradigm change: cell growth is controlled
title_full TOR and paradigm change: cell growth is controlled
title_fullStr TOR and paradigm change: cell growth is controlled
title_full_unstemmed TOR and paradigm change: cell growth is controlled
title_short TOR and paradigm change: cell growth is controlled
title_sort tor and paradigm change: cell growth is controlled
topic Retrospectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025266/
https://www.ncbi.nlm.nih.gov/pubmed/27634743
http://dx.doi.org/10.1091/mbc.E15-05-0311
work_keys_str_mv AT hallmichaeln torandparadigmchangecellgrowthiscontrolled

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