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Rhabdomyolysis in a patient taking nebivolol
β Blockers such as propranolol and labetalol are known to induce toxic myopathy because of their partial β(2) adrenoceptor agonistic effect. Nebivolol has the highest β(1) receptor affinity among β blockers, and it has never been reported to induce rhabdomyolysis until now. We report a patient who d...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025462/ https://www.ncbi.nlm.nih.gov/pubmed/27668163 http://dx.doi.org/10.1016/j.krcp.2015.09.003 |
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author | Kim, Ye Jin Kim, Hae Ri Jeon, Hong Jae Ju, Hyun Jun Chung, Sarah Choi, Dae Eun Lee, Kang Wook Na, Ki Ryang |
author_facet | Kim, Ye Jin Kim, Hae Ri Jeon, Hong Jae Ju, Hyun Jun Chung, Sarah Choi, Dae Eun Lee, Kang Wook Na, Ki Ryang |
author_sort | Kim, Ye Jin |
collection | PubMed |
description | β Blockers such as propranolol and labetalol are known to induce toxic myopathy because of their partial β(2) adrenoceptor agonistic effect. Nebivolol has the highest β(1) receptor affinity among β blockers, and it has never been reported to induce rhabdomyolysis until now. We report a patient who developed rhabdomyolysis after changing medication to nebivolol. A 75-year-old woman was admitted to our hospital because of generalized weakness originating 2 weeks before visiting. Approximately 1 month before her admission, her medication was changed from carvedilol 12.5 mg to nebivolol 5 mg. Over this time span, she had no other lifestyle changes causing rhabdomyolysis. Her blood chemistry and whole body bone scan indicated rhabdomyolysis. We considered newly prescribed nebivolol as a causal agent. She was prescribed carvedilol 12.5 mg, which she was previously taking, instead of nebivolol. She was treated by hydration and urine alkalization. She had fully recovered and was discharged. |
format | Online Article Text |
id | pubmed-5025462 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-50254622016-09-23 Rhabdomyolysis in a patient taking nebivolol Kim, Ye Jin Kim, Hae Ri Jeon, Hong Jae Ju, Hyun Jun Chung, Sarah Choi, Dae Eun Lee, Kang Wook Na, Ki Ryang Kidney Res Clin Pract Case Report β Blockers such as propranolol and labetalol are known to induce toxic myopathy because of their partial β(2) adrenoceptor agonistic effect. Nebivolol has the highest β(1) receptor affinity among β blockers, and it has never been reported to induce rhabdomyolysis until now. We report a patient who developed rhabdomyolysis after changing medication to nebivolol. A 75-year-old woman was admitted to our hospital because of generalized weakness originating 2 weeks before visiting. Approximately 1 month before her admission, her medication was changed from carvedilol 12.5 mg to nebivolol 5 mg. Over this time span, she had no other lifestyle changes causing rhabdomyolysis. Her blood chemistry and whole body bone scan indicated rhabdomyolysis. We considered newly prescribed nebivolol as a causal agent. She was prescribed carvedilol 12.5 mg, which she was previously taking, instead of nebivolol. She was treated by hydration and urine alkalization. She had fully recovered and was discharged. Elsevier 2016-09 2016-01-22 /pmc/articles/PMC5025462/ /pubmed/27668163 http://dx.doi.org/10.1016/j.krcp.2015.09.003 Text en Copyright © 2016. The Korean Society of Nephrology. Published by Elsevier. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Kim, Ye Jin Kim, Hae Ri Jeon, Hong Jae Ju, Hyun Jun Chung, Sarah Choi, Dae Eun Lee, Kang Wook Na, Ki Ryang Rhabdomyolysis in a patient taking nebivolol |
title | Rhabdomyolysis in a patient taking nebivolol |
title_full | Rhabdomyolysis in a patient taking nebivolol |
title_fullStr | Rhabdomyolysis in a patient taking nebivolol |
title_full_unstemmed | Rhabdomyolysis in a patient taking nebivolol |
title_short | Rhabdomyolysis in a patient taking nebivolol |
title_sort | rhabdomyolysis in a patient taking nebivolol |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025462/ https://www.ncbi.nlm.nih.gov/pubmed/27668163 http://dx.doi.org/10.1016/j.krcp.2015.09.003 |
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