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Expression of metalloproteinases (MMP-2 and MMP-9) in basal-cell carcinoma

The aim of this study was to compare the expressions of mRNA for metalloproteinases (MMP-2 and MMP-9) and type IV collagen in two different histological types of basal-cell carcinoma (BCCs; nodular and infiltrative) and in normal tissues from the tumor interface. The study included biopsy specimens...

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Autores principales: Goździalska, Anna, Wojas-Pelc, Anna, Drąg, Jagoda, Brzewski, Paweł, Jaśkiewicz, Jerzy, Pastuszczak, Maciej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025502/
https://www.ncbi.nlm.nih.gov/pubmed/27406386
http://dx.doi.org/10.1007/s11033-016-4040-9
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author Goździalska, Anna
Wojas-Pelc, Anna
Drąg, Jagoda
Brzewski, Paweł
Jaśkiewicz, Jerzy
Pastuszczak, Maciej
author_facet Goździalska, Anna
Wojas-Pelc, Anna
Drąg, Jagoda
Brzewski, Paweł
Jaśkiewicz, Jerzy
Pastuszczak, Maciej
author_sort Goździalska, Anna
collection PubMed
description The aim of this study was to compare the expressions of mRNA for metalloproteinases (MMP-2 and MMP-9) and type IV collagen in two different histological types of basal-cell carcinoma (BCCs; nodular and infiltrative) and in normal tissues from the tumor interface. The study included biopsy specimens of the skin involved with BCC and normal skin adjacent the lesion. The expressions of mRNA for MMP-2, MMP-9 and type IV collagen were determined by means of RT-PCR (Reverse transcription polymerase chain reaction). The level of type IV collagen mRNA in nodular and infiltrative BCCs turned out to be significantly lower, and the expressions of MMP-2 and MMP-9 mRNA significantly higher than in normal tissues adjacent to these tumors. The expression of mRNA for MMP-9 but not for MMP-2 was significantly higher in infiltrative BCCs than in the nodular BCCs. In turn, normal tissues adjacent to nodular BCCs showed significantly higher levels of mRNA for MMP-2 and significantly lower levels of type IV collagen mRNA than the normal tissues from the interface of infiltrative BCCs. The findings suggest that MMP-2 and MMP-9 could be used as prognostic factors of BCCs.
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spelling pubmed-50255022016-09-29 Expression of metalloproteinases (MMP-2 and MMP-9) in basal-cell carcinoma Goździalska, Anna Wojas-Pelc, Anna Drąg, Jagoda Brzewski, Paweł Jaśkiewicz, Jerzy Pastuszczak, Maciej Mol Biol Rep Short Communication The aim of this study was to compare the expressions of mRNA for metalloproteinases (MMP-2 and MMP-9) and type IV collagen in two different histological types of basal-cell carcinoma (BCCs; nodular and infiltrative) and in normal tissues from the tumor interface. The study included biopsy specimens of the skin involved with BCC and normal skin adjacent the lesion. The expressions of mRNA for MMP-2, MMP-9 and type IV collagen were determined by means of RT-PCR (Reverse transcription polymerase chain reaction). The level of type IV collagen mRNA in nodular and infiltrative BCCs turned out to be significantly lower, and the expressions of MMP-2 and MMP-9 mRNA significantly higher than in normal tissues adjacent to these tumors. The expression of mRNA for MMP-9 but not for MMP-2 was significantly higher in infiltrative BCCs than in the nodular BCCs. In turn, normal tissues adjacent to nodular BCCs showed significantly higher levels of mRNA for MMP-2 and significantly lower levels of type IV collagen mRNA than the normal tissues from the interface of infiltrative BCCs. The findings suggest that MMP-2 and MMP-9 could be used as prognostic factors of BCCs. Springer Netherlands 2016-07-12 2016 /pmc/articles/PMC5025502/ /pubmed/27406386 http://dx.doi.org/10.1007/s11033-016-4040-9 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Short Communication
Goździalska, Anna
Wojas-Pelc, Anna
Drąg, Jagoda
Brzewski, Paweł
Jaśkiewicz, Jerzy
Pastuszczak, Maciej
Expression of metalloproteinases (MMP-2 and MMP-9) in basal-cell carcinoma
title Expression of metalloproteinases (MMP-2 and MMP-9) in basal-cell carcinoma
title_full Expression of metalloproteinases (MMP-2 and MMP-9) in basal-cell carcinoma
title_fullStr Expression of metalloproteinases (MMP-2 and MMP-9) in basal-cell carcinoma
title_full_unstemmed Expression of metalloproteinases (MMP-2 and MMP-9) in basal-cell carcinoma
title_short Expression of metalloproteinases (MMP-2 and MMP-9) in basal-cell carcinoma
title_sort expression of metalloproteinases (mmp-2 and mmp-9) in basal-cell carcinoma
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025502/
https://www.ncbi.nlm.nih.gov/pubmed/27406386
http://dx.doi.org/10.1007/s11033-016-4040-9
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