An alternative novel tool for DNA editing without target sequence limitation: the structure-guided nuclease

Engineered endonucleases are a powerful tool for editing DNA. However, sequence preferences may limit their application. We engineer a structure-guided endonuclease (SGN) composed of flap endonuclease-1 (FEN-1), which recognizes the 3′ flap structure, and the cleavage domain of Fok I (Fn1), which cl...

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Detalles Bibliográficos
Autores principales: Xu, Shu, Cao, Shasha, Zou, Bingjie, Yue, Yunyun, Gu, Chun, Chen, Xin, Wang, Pei, Dong, Xiaohua, Xiang, Zheng, Li, Kai, Zhu, Minsheng, Zhao, Qingshun, Zhou, Guohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025552/
https://www.ncbi.nlm.nih.gov/pubmed/27634179
http://dx.doi.org/10.1186/s13059-016-1038-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025552/
https://www.ncbi.nlm.nih.gov/pubmed/27634179
http://dx.doi.org/10.1186/s13059-016-1038-5

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