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An alternative novel tool for DNA editing without target sequence limitation: the structure-guided nuclease

Engineered endonucleases are a powerful tool for editing DNA. However, sequence preferences may limit their application. We engineer a structure-guided endonuclease (SGN) composed of flap endonuclease-1 (FEN-1), which recognizes the 3′ flap structure, and the cleavage domain of Fok I (Fn1), which cl...

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Detalles Bibliográficos
Autores principales:	Xu, Shu, Cao, Shasha, Zou, Bingjie, Yue, Yunyun, Gu, Chun, Chen, Xin, Wang, Pei, Dong, Xiaohua, Xiang, Zheng, Li, Kai, Zhu, Minsheng, Zhao, Qingshun, Zhou, Guohua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Method
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025552/ https://www.ncbi.nlm.nih.gov/pubmed/27634179 http://dx.doi.org/10.1186/s13059-016-1038-5

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