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Deep vein thrombosis resolution, recurrence and post-thrombotic syndrome: a prospective observational study protocol

BACKGROUND: Reasons for the variation in response of deep vein thrombosis (DVT) to anticoagulation treatment are not known. Some patients develop complications such as post-thrombotic syndrome or recurrent DVT but others make a full recovery. The aim of the study is to identify the level of variatio...

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Autores principales: Bonfield, M., Cramp, F., Pollock, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025593/
https://www.ncbi.nlm.nih.gov/pubmed/27651905
http://dx.doi.org/10.1186/s12878-016-0063-7
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author Bonfield, M.
Cramp, F.
Pollock, J.
author_facet Bonfield, M.
Cramp, F.
Pollock, J.
author_sort Bonfield, M.
collection PubMed
description BACKGROUND: Reasons for the variation in response of deep vein thrombosis (DVT) to anticoagulation treatment are not known. Some patients develop complications such as post-thrombotic syndrome or recurrent DVT but others make a full recovery. The aim of the study is to identify the level of variation in response to anticoagulation treatment and provide more precise and quantitative disease characterisation in response to treatment. METHODS: A prospective observational study using duplex ultrasound to examine changes in thrombus characterisation, evolution and resolution over a 2 year period in patients with a confirmed DVT. Logistic regression analysis will be used to seek associations between characteristics present at baseline and the outcomes of DVT resolution, recurrence and the development of post-thrombotic syndrome (PTS). DISCUSSION: This research into the response to treatment of lower limb DVT and predictive factors for DVT resolution, recurrence and PTS could inform a more tailored approach to anticoagulation therapy for the future management of DVT. UKCRN ID: 16016. Registered on 20 January 2014.
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spelling pubmed-50255932016-09-20 Deep vein thrombosis resolution, recurrence and post-thrombotic syndrome: a prospective observational study protocol Bonfield, M. Cramp, F. Pollock, J. BMC Hematol Study Protocol BACKGROUND: Reasons for the variation in response of deep vein thrombosis (DVT) to anticoagulation treatment are not known. Some patients develop complications such as post-thrombotic syndrome or recurrent DVT but others make a full recovery. The aim of the study is to identify the level of variation in response to anticoagulation treatment and provide more precise and quantitative disease characterisation in response to treatment. METHODS: A prospective observational study using duplex ultrasound to examine changes in thrombus characterisation, evolution and resolution over a 2 year period in patients with a confirmed DVT. Logistic regression analysis will be used to seek associations between characteristics present at baseline and the outcomes of DVT resolution, recurrence and the development of post-thrombotic syndrome (PTS). DISCUSSION: This research into the response to treatment of lower limb DVT and predictive factors for DVT resolution, recurrence and PTS could inform a more tailored approach to anticoagulation therapy for the future management of DVT. UKCRN ID: 16016. Registered on 20 January 2014. BioMed Central 2016-09-15 /pmc/articles/PMC5025593/ /pubmed/27651905 http://dx.doi.org/10.1186/s12878-016-0063-7 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Study Protocol
Bonfield, M.
Cramp, F.
Pollock, J.
Deep vein thrombosis resolution, recurrence and post-thrombotic syndrome: a prospective observational study protocol
title Deep vein thrombosis resolution, recurrence and post-thrombotic syndrome: a prospective observational study protocol
title_full Deep vein thrombosis resolution, recurrence and post-thrombotic syndrome: a prospective observational study protocol
title_fullStr Deep vein thrombosis resolution, recurrence and post-thrombotic syndrome: a prospective observational study protocol
title_full_unstemmed Deep vein thrombosis resolution, recurrence and post-thrombotic syndrome: a prospective observational study protocol
title_short Deep vein thrombosis resolution, recurrence and post-thrombotic syndrome: a prospective observational study protocol
title_sort deep vein thrombosis resolution, recurrence and post-thrombotic syndrome: a prospective observational study protocol
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025593/
https://www.ncbi.nlm.nih.gov/pubmed/27651905
http://dx.doi.org/10.1186/s12878-016-0063-7
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