Protein Folding Activity of the Ribosome is involved in Yeast Prion Propagation

6AP and GA are potent inhibitors of yeast and mammalian prions and also specific inhibitors of PFAR, the protein-folding activity borne by domain V of the large rRNA of the large subunit of the ribosome. We therefore explored the link between PFAR and yeast prion [PSI(+)] using both PFAR-enriched mu...

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Detalles Bibliográficos
Autores principales: Blondel, Marc, Soubigou, Flavie, Evrard, Justine, Nguyen, Phu hai, Hasin, Naushaba, Chédin, Stéphane, Gillet, Reynald, Contesse, Marie-Astrid, Friocourt, Gaëlle, Stahl, Guillaume, Jones, Gary W., Voisset, Cécile
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025663/
https://www.ncbi.nlm.nih.gov/pubmed/27633137
http://dx.doi.org/10.1038/srep32117

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