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Hypothalamic volume loss is associated with reduced melatonin output in Parkinson's disease
BACKGROUND: Recent studies have suggested that melatonin—a hormone produced by the pineal gland under circadian control—contributes to PD‐related sleep dysfunction. We hypothesized that degenerative changes to the neural structures controlling pineal function (especially the suprachiasmatic nuclei o...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025727/ https://www.ncbi.nlm.nih.gov/pubmed/26971528 http://dx.doi.org/10.1002/mds.26592 |
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author | Breen, David P. Nombela, Cristina Vuono, Romina Jones, P. Simon Fisher, Kate Burn, David J. Brooks, David J. Reddy, Akhilesh B. Rowe, James B. Barker, Roger A. |
author_facet | Breen, David P. Nombela, Cristina Vuono, Romina Jones, P. Simon Fisher, Kate Burn, David J. Brooks, David J. Reddy, Akhilesh B. Rowe, James B. Barker, Roger A. |
author_sort | Breen, David P. |
collection | PubMed |
description | BACKGROUND: Recent studies have suggested that melatonin—a hormone produced by the pineal gland under circadian control—contributes to PD‐related sleep dysfunction. We hypothesized that degenerative changes to the neural structures controlling pineal function (especially the suprachiasmatic nuclei of the anterior hypothalamus) may be responsible for reduced melatonin output in these patients. We compared hypothalamic volumes in PD patients with matched controls and determined whether volume loss correlated with reduced melatonin output in the PD group. METHODS: A total of 12 PD patients and 12 matched controls underwent magnetic resonance imaging to determine hypothalamic volume. In addition, PD patients underwent 24‐hour blood sampling in a controlled environment to determine serum melatonin concentrations using enzyme‐linked immunosorbent assays. RESULTS: PD patients had significantly reduced hypothalamic gray matter volume when compared with matched controls. Melatonin levels were significantly associated with hypothalamic gray matter volume and disease severity in PD patients. CONCLUSION: Melatonin levels are associated with hypothalamic gray matter volume loss and disease severity in PD patients. This provides anatomical and physiological support for an intrinsic sleep and circadian phenotype in PD. © 2016 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society |
format | Online Article Text |
id | pubmed-5025727 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-50257272016-10-03 Hypothalamic volume loss is associated with reduced melatonin output in Parkinson's disease Breen, David P. Nombela, Cristina Vuono, Romina Jones, P. Simon Fisher, Kate Burn, David J. Brooks, David J. Reddy, Akhilesh B. Rowe, James B. Barker, Roger A. Mov Disord Brief Reports BACKGROUND: Recent studies have suggested that melatonin—a hormone produced by the pineal gland under circadian control—contributes to PD‐related sleep dysfunction. We hypothesized that degenerative changes to the neural structures controlling pineal function (especially the suprachiasmatic nuclei of the anterior hypothalamus) may be responsible for reduced melatonin output in these patients. We compared hypothalamic volumes in PD patients with matched controls and determined whether volume loss correlated with reduced melatonin output in the PD group. METHODS: A total of 12 PD patients and 12 matched controls underwent magnetic resonance imaging to determine hypothalamic volume. In addition, PD patients underwent 24‐hour blood sampling in a controlled environment to determine serum melatonin concentrations using enzyme‐linked immunosorbent assays. RESULTS: PD patients had significantly reduced hypothalamic gray matter volume when compared with matched controls. Melatonin levels were significantly associated with hypothalamic gray matter volume and disease severity in PD patients. CONCLUSION: Melatonin levels are associated with hypothalamic gray matter volume loss and disease severity in PD patients. This provides anatomical and physiological support for an intrinsic sleep and circadian phenotype in PD. © 2016 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society John Wiley and Sons Inc. 2016-03-12 2016-07 /pmc/articles/PMC5025727/ /pubmed/26971528 http://dx.doi.org/10.1002/mds.26592 Text en © 2016 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Brief Reports Breen, David P. Nombela, Cristina Vuono, Romina Jones, P. Simon Fisher, Kate Burn, David J. Brooks, David J. Reddy, Akhilesh B. Rowe, James B. Barker, Roger A. Hypothalamic volume loss is associated with reduced melatonin output in Parkinson's disease |
title | Hypothalamic volume loss is associated with reduced melatonin output in Parkinson's disease |
title_full | Hypothalamic volume loss is associated with reduced melatonin output in Parkinson's disease |
title_fullStr | Hypothalamic volume loss is associated with reduced melatonin output in Parkinson's disease |
title_full_unstemmed | Hypothalamic volume loss is associated with reduced melatonin output in Parkinson's disease |
title_short | Hypothalamic volume loss is associated with reduced melatonin output in Parkinson's disease |
title_sort | hypothalamic volume loss is associated with reduced melatonin output in parkinson's disease |
topic | Brief Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025727/ https://www.ncbi.nlm.nih.gov/pubmed/26971528 http://dx.doi.org/10.1002/mds.26592 |
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