Bach2–Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop

Although Bach2 has an important role in regulating the Th2-type immune response, the underlying molecular mechanisms remain unclear. We herein demonstrate that Bach2 associates with Batf and binds to the regulatory regions of the Th2 cytokine gene loci. The Bach2–Batf complex antagonizes the recruit...

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Detalles Bibliográficos
Autores principales: Kuwahara, Makoto, Ise, Wataru, Ochi, Mizuki, Suzuki, Junpei, Kometani, Kohei, Maruyama, Saho, Izumoto, Maya, Matsumoto, Akira, Takemori, Nobuaki, Takemori, Ayako, Shinoda, Kenta, Nakayama, Toshinori, Ohara, Osamu, Yasukawa, Masaki, Sawasaki, Tatsuya, Kurosaki, Tomohiro, Yamashita, Masakatsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025763/
https://www.ncbi.nlm.nih.gov/pubmed/27581382
http://dx.doi.org/10.1038/ncomms12596

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