Retinal orientation and interactions in rhodopsin reveal a two-stage trigger mechanism for activation

The 11-cis retinal chromophore is tightly packed within the interior of the visual receptor rhodopsin and isomerizes to the all-trans configuration following absorption of light. The mechanism by which this isomerization event drives the outward rotation of transmembrane helix H6, a hallmark of acti...

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Detalles Bibliográficos
Autores principales: Kimata, Naoki, Pope, Andreyah, Eilers, Markus, Opefi, Chikwado A., Ziliox, Martine, Hirshfeld, Amiram, Zaitseva, Ekaterina, Vogel, Reiner, Sheves, Mordechai, Reeves, Philip J., Smith, Steven O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025775/
https://www.ncbi.nlm.nih.gov/pubmed/27585742
http://dx.doi.org/10.1038/ncomms12683

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025775/
https://www.ncbi.nlm.nih.gov/pubmed/27585742
http://dx.doi.org/10.1038/ncomms12683

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