Towards Biocontained Cell Factories: An Evolutionarily Adapted Escherichia coli Strain Produces a New-to-nature Bioactive Lantibiotic Containing Thienopyrrole-Alanine

Genetic code engineering that enables reassignment of genetic codons to non-canonical amino acids (ncAAs) is a powerful strategy for enhancing ribosomally synthesized peptides and proteins with functions not commonly found in Nature. Here we report the expression of a ribosomally synthesized and pos...

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Detalles Bibliográficos
Autores principales: Kuthning, Anja, Durkin, Patrick, Oehm, Stefan, Hoesl, Michael G., Budisa, Nediljko, Süssmuth, Roderich D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025777/
https://www.ncbi.nlm.nih.gov/pubmed/27634138
http://dx.doi.org/10.1038/srep33447

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