Dysfunctional cerebellar Purkinje cells contribute to autism-like behaviour in Shank2-deficient mice

Loss-of-function mutations in the gene encoding the postsynaptic scaffolding protein SHANK2 are a highly penetrant cause of autism spectrum disorders (ASD) involving cerebellum-related motor problems. Recent studies have implicated cerebellar pathology in the aetiology of ASD. Here we evaluate the p...

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Detalles Bibliográficos
Autores principales: Peter, Saša, ten Brinke, Michiel M., Stedehouder, Jeffrey, Reinelt, Claudia M., Wu, Bin, Zhou, Haibo, Zhou, Kuikui, Boele, Henk-Jan, Kushner, Steven A., Lee, Min Goo, Schmeisser, Michael J., Boeckers, Tobias M., Schonewille, Martijn, Hoebeek, Freek E., De Zeeuw, Chris I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025785/
https://www.ncbi.nlm.nih.gov/pubmed/27581745
http://dx.doi.org/10.1038/ncomms12627

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025785/
https://www.ncbi.nlm.nih.gov/pubmed/27581745
http://dx.doi.org/10.1038/ncomms12627

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