ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival

Metabolic pathways are reprogrammed in cancer to support cell survival. Here, we report that T-cell acute lymphoblastic leukemia (T-ALL) cells are characterized by increased oxidative phosphorylation and robust ATP production. We demonstrate that ORP4L is expressed in T-ALL but not normal T-cells an...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhong, Wenbin, Yi, Qing, Xu, Bing, Li, Shiqian, Wang, Tong, Liu, Fupei, Zhu, Biying, Hoffmann, Peter R., Ji, Guangju, Lei, Pingsheng, Li, Guoping, Li, Jiwei, Li, Jian, Olkkonen, Vesa M., Yan, Daoguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025801/
https://www.ncbi.nlm.nih.gov/pubmed/27581363
http://dx.doi.org/10.1038/ncomms12702

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025801/
https://www.ncbi.nlm.nih.gov/pubmed/27581363
http://dx.doi.org/10.1038/ncomms12702

Ejemplares similares