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Clonal dynamics following p53 loss of heterozygosity in Kras-driven cancers

Although it has become increasingly clear that cancers display extensive cellular heterogeneity, the spatial growth dynamics of genetically distinct clones within developing solid tumours remain poorly understood. Here we leverage mosaic analysis with double markers (MADM) to trace subclonal populat...

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Detalles Bibliográficos
Autores principales:	Muzumdar, Mandar Deepak, Dorans, Kimberly Judith, Chung, Katherine Minjee, Robbins, Rebecca, Tammela, Tuomas, Gocheva, Vasilena, Li, Carman Man-Chung, Jacks, Tyler
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025814/ https://www.ncbi.nlm.nih.gov/pubmed/27585860 http://dx.doi.org/10.1038/ncomms12685

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