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THBS2 is a Potential Prognostic Biomarker in Colorectal Cancer
Colorectal cancer is one of the most common leading causes of death worldwide. Prognostic at an early stage is a useful way that decrease and avoid mortality. Although remarkable progress has been made to investigate the underlying mechanism, the understanding of the complicated carcinogenesis proce...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025892/ https://www.ncbi.nlm.nih.gov/pubmed/27632935 http://dx.doi.org/10.1038/srep33366 |
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author | Wang, Xue Zhang, Lei Li, Hui Sun, WenJie Zhang, Honghe Lai, Maode |
author_facet | Wang, Xue Zhang, Lei Li, Hui Sun, WenJie Zhang, Honghe Lai, Maode |
author_sort | Wang, Xue |
collection | PubMed |
description | Colorectal cancer is one of the most common leading causes of death worldwide. Prognostic at an early stage is a useful way that decrease and avoid mortality. Although remarkable progress has been made to investigate the underlying mechanism, the understanding of the complicated carcinogenesis process was enormously hindered by large-scale tumor heterogeneity. Here we proposed that the prognosis-related gene THBS2, responsible for cooperativity disorientation, probably contain untapped prognostic resource of colorectal cancer. We originally established Spearman correlation transition, Kaplan–Meier survival analysis and meta-analysis that combine public dataset and clinical samples to quantify the prognostic value of THBS2. THBS2 could be considered as a novel prognostic marker in colorectal cancer. |
format | Online Article Text |
id | pubmed-5025892 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-50258922016-09-22 THBS2 is a Potential Prognostic Biomarker in Colorectal Cancer Wang, Xue Zhang, Lei Li, Hui Sun, WenJie Zhang, Honghe Lai, Maode Sci Rep Article Colorectal cancer is one of the most common leading causes of death worldwide. Prognostic at an early stage is a useful way that decrease and avoid mortality. Although remarkable progress has been made to investigate the underlying mechanism, the understanding of the complicated carcinogenesis process was enormously hindered by large-scale tumor heterogeneity. Here we proposed that the prognosis-related gene THBS2, responsible for cooperativity disorientation, probably contain untapped prognostic resource of colorectal cancer. We originally established Spearman correlation transition, Kaplan–Meier survival analysis and meta-analysis that combine public dataset and clinical samples to quantify the prognostic value of THBS2. THBS2 could be considered as a novel prognostic marker in colorectal cancer. Nature Publishing Group 2016-09-16 /pmc/articles/PMC5025892/ /pubmed/27632935 http://dx.doi.org/10.1038/srep33366 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Wang, Xue Zhang, Lei Li, Hui Sun, WenJie Zhang, Honghe Lai, Maode THBS2 is a Potential Prognostic Biomarker in Colorectal Cancer |
title | THBS2 is a Potential Prognostic Biomarker in Colorectal Cancer |
title_full | THBS2 is a Potential Prognostic Biomarker in Colorectal Cancer |
title_fullStr | THBS2 is a Potential Prognostic Biomarker in Colorectal Cancer |
title_full_unstemmed | THBS2 is a Potential Prognostic Biomarker in Colorectal Cancer |
title_short | THBS2 is a Potential Prognostic Biomarker in Colorectal Cancer |
title_sort | thbs2 is a potential prognostic biomarker in colorectal cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025892/ https://www.ncbi.nlm.nih.gov/pubmed/27632935 http://dx.doi.org/10.1038/srep33366 |
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