Do corticosteroids play a role in the management of traumatic brain injury?

Neuroprotective strategies for the medical management of traumatic brain injury (TBI) have been elusive. While laboratory studies provide a conceptual framework for the potential efficacy of corticosteroids in this context, clinical trials testing this hypothesis have yielded no convincing evidence...

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Autores principales: Hoshide, Reid, Cheung, Vincent, Marshall, Lawrence, Kasper, Ekkehard, Chen, Clark C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025911/
https://www.ncbi.nlm.nih.gov/pubmed/27656315
http://dx.doi.org/10.4103/2152-7806.190439
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author Hoshide, Reid
Cheung, Vincent
Marshall, Lawrence
Kasper, Ekkehard
Chen, Clark C.
author_facet Hoshide, Reid
Cheung, Vincent
Marshall, Lawrence
Kasper, Ekkehard
Chen, Clark C.
author_sort Hoshide, Reid
collection PubMed
description Neuroprotective strategies for the medical management of traumatic brain injury (TBI) have been elusive. While laboratory studies provide a conceptual framework for the potential efficacy of corticosteroids in this context, clinical trials testing this hypothesis have yielded no convincing evidence of clinical benefit. Here, we review the five key randomized control trials (RCTs) that have examined this issue. Based on the proposed primary endpoints of these RCTs, the five RCTs consistently showed that corticosteroids do not confer significant benefit in the TBI population.
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spelling pubmed-50259112016-09-21 Do corticosteroids play a role in the management of traumatic brain injury? Hoshide, Reid Cheung, Vincent Marshall, Lawrence Kasper, Ekkehard Chen, Clark C. Surg Neurol Int Editorial Neuroprotective strategies for the medical management of traumatic brain injury (TBI) have been elusive. While laboratory studies provide a conceptual framework for the potential efficacy of corticosteroids in this context, clinical trials testing this hypothesis have yielded no convincing evidence of clinical benefit. Here, we review the five key randomized control trials (RCTs) that have examined this issue. Based on the proposed primary endpoints of these RCTs, the five RCTs consistently showed that corticosteroids do not confer significant benefit in the TBI population. Medknow Publications & Media Pvt Ltd 2016-09-13 /pmc/articles/PMC5025911/ /pubmed/27656315 http://dx.doi.org/10.4103/2152-7806.190439 Text en Copyright: © 2016 Surgical Neurology International http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Editorial
Hoshide, Reid
Cheung, Vincent
Marshall, Lawrence
Kasper, Ekkehard
Chen, Clark C.
Do corticosteroids play a role in the management of traumatic brain injury?
title Do corticosteroids play a role in the management of traumatic brain injury?
title_full Do corticosteroids play a role in the management of traumatic brain injury?
title_fullStr Do corticosteroids play a role in the management of traumatic brain injury?
title_full_unstemmed Do corticosteroids play a role in the management of traumatic brain injury?
title_short Do corticosteroids play a role in the management of traumatic brain injury?
title_sort do corticosteroids play a role in the management of traumatic brain injury?
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025911/
https://www.ncbi.nlm.nih.gov/pubmed/27656315
http://dx.doi.org/10.4103/2152-7806.190439
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AT kasperekkehard docorticosteroidsplayaroleinthemanagementoftraumaticbraininjury
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