Glycation in Demetalated Superoxide Dismutase 1 Prevents Amyloid Aggregation and Produces Cytotoxic Ages Adducts

Superoxide dismutase 1 (SOD1) has been implicated with familial amyotrophic lateral sclerosis (fALS) through accumulation of protein amyloid aggregates in motor neurons of patients. Amyloid aggregates and protein inclusions are a common pathological feature of many neurological disorders in which pr...

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Detalles Bibliográficos
Autores principales: Sirangelo, Ivana, Vella, Filomena M., Irace, Gaetano, Manco, Giuseppe, Iannuzzi, Clara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026054/
https://www.ncbi.nlm.nih.gov/pubmed/27695694
http://dx.doi.org/10.3389/fmolb.2016.00055

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