Cargando…

Three‐Dimensional Model of Human Nicotinamide Nucleotide Transhydrogenase (NNT) and Sequence‐Structure Analysis of its Disease‐Causing Variations

Defective mitochondrial proteins are emerging as major contributors to human disease. Nicotinamide nucleotide transhydrogenase (NNT), a widely expressed mitochondrial protein, has a crucial role in the defence against oxidative stress. NNT variations have recently been reported in patients with fami...

Descripción completa

Detalles Bibliográficos
Autores principales:	Metherell, Louise A, Guerra‐Assunção, José Afonso, Sternberg, Michael J, David, Alessia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026163/ https://www.ncbi.nlm.nih.gov/pubmed/27459240 http://dx.doi.org/10.1002/humu.23046

Ejemplares similares

Mutations in Nicotinamide Nucleotide Transhydrogenase (NNT) cause familial glucocorticoid deficiency
por: Meimaridou, Eirini, et al.
Publicado: (2012)

Nicotinamide nucleotide transhydrogenase (NNT) deficiency dysregulates mitochondrial retrograde signaling and impedes proliferation
por: Ho, Hung-Yao, et al.
Publicado: (2017)

Nicotinamide nucleotide transhydrogenase (NNT) regulates mitochondrial ROS and endothelial dysfunction in response to angiotensin II
por: Rao, K.N. Shashanka, et al.
Publicado: (2020)

Saturated Fatty Acid Activates T Cell Inflammation Through a Nicotinamide Nucleotide Transhydrogenase (NNT)-Dependent Mechanism
por: McCambridge, Grace, et al.
Publicado: (2019)

SAT343 Nicotinamide Nucleotide Transhydrogenase (NNT)-related Familial Glucocorticoid Deficiency: More Than Adrenal Insufficiency
por: Shanker, Anita, et al.
Publicado: (2023)

Nicotinamide Nucleotide Transhydrogenase as a Novel Treatment Target in Adrenocortical Carcinoma
por: Chortis, Vasileios, et al.
Publicado: (2018)

Testicular impairment in Primary Adrenal Insufficiency caused by Nicotinamide Nucleotide Transhydrogenase (NNT) deficiency - a case report: implication of oxidative stress and importance of fertility preservation
por: Ferreux, Lucile, et al.
Publicado: (2023)

Proton-Translocating Nicotinamide Nucleotide Transhydrogenase: A Structural Perspective
por: Zhang, Qinghai, et al.
Publicado: (2017)

Transcription Levels of nicotinamide nucleotide transhydrogenase and Its Antisense in Breast Cancer Samples
por: Saleh Gargari, Soraya, et al.
Publicado: (2019)

Energy transfer between the nicotinamide nucleotide transhydrogenase and ATP synthase of Escherichia coli
por: Graf, Simone Sandra, et al.
Publicado: (2021)

The Combination of Niacinamide, Vitamin C, and PDRN Mitigates Melanogenesis by Modulating Nicotinamide Nucleotide Transhydrogenase
por: Park, Hyun Jun, et al.
Publicado: (2022)

Dysregulation of glucose homeostasis in nicotinamide nucleotide transhydrogenase knockout mice is independent of uncoupling protein 2
por: Parker, Nadeene, et al.
Publicado: (2009)

Nicotinamide nucleotide transhydrogenase-mediated redox homeostasis promotes tumor growth and metastasis in gastric cancer
por: Li, Shuai, et al.
Publicado: (2018)

Nicotinamide nucleotide transhydrogenase regulates mitochondrial metabolism in NSCLC through maintenance of Fe-S protein function
por: Ward, Nathan P., et al.
Publicado: (2020)

Reverse Reaction of Nicotinamide Nucleotide Transhydrogenase Promotes ROS Production and Contributes to Right Ventricular Failure
por: Lemay, Sarah-Eve, et al.
Publicado: (2022)

Upregulated expression of LncRNA nicotinamide nucleotide transhydrogenase antisense RNA 1 is correlated with unfavorable clinical outcomes in cancers
por: Zhang, Chenghao, et al.
Publicado: (2020)

Factors Influencing Mitochondrial Function as a Key Mediator of Glucose-Induced Insulin Release: Highlighting Nicotinamide Nucleotide Transhydrogenase
por: Aghelan, Zahra, et al.
Publicado: (2020)

Ligand binding and conformational dynamics of the E. coli nicotinamide nucleotide transhydrogenase revealed by hydrogen/deuterium exchange mass spectrometry
por: Zöller, Jonathan, et al.
Publicado: (2022)

Impact of a novel homozygous mutation in nicotinamide nucleotide transhydrogenase on mitochondrial DNA integrity in a case of familial glucocorticoid deficiency
por: Fujisawa, Yasuko, et al.
Publicado: (2014)

Loss of Nicotinamide nucleotide transhydrogenase sensitizes embryos to ethanol-induced neural crest and neural apoptosis via generation of reactive oxygen species
por: Mazumdar, Rayna, et al.
Publicado: (2023)

Can NAD(P)(+) transhydrogenase (NNT) mediate a physiologically meaningful increase in energy expenditure by mitochondria during H(2)O(2) removal?
por: Figueira, Tiago R., et al.
Publicado: (2021)

ODP055 The methylation pattern of a unique Bilateral para-overian Adrenal Rest Tumor in a girl with Nicotinamide Nucleotide Transhydrogenase mutation
por: Cahn, Ranit, et al.
Publicado: (2022)

NNT is a key regulator of adrenal redox homeostasis and steroidogenesis in male mice
por: Meimaridou, E, et al.
Publicado: (2017)

Reply to Figueira et al.: Can NAD(P)(+) transhydrogenase (NNT) mediate a physiologically meaningful increase in energy expenditure by mitochondria during H(2)O(2) removal?
por: Smith, Cody D., et al.
Publicado: (2021)

NNT Pseudoexon Activation as a Novel Mechanism for Disease in Two Siblings With Familial Glucocorticoid Deficiency
por: Novoselova, Tatiana V., et al.
Publicado: (2015)

Loss of Nnt Increases Expression of Oxidative Phosphorylation Complexes in C57BL/6J Hearts
por: Williams, Jack L., et al.
Publicado: (2021)

A conserved sequence motif in the Escherichia coli soluble FAD-containing pyridine nucleotide transhydrogenase is important for reaction efficiency
por: Partipilo, Michele, et al.
Publicado: (2022)

NNT in NSCLC: No need to worry?
por: Conrad, Marcus
Publicado: (2020)

Severe Virilization in a Girl With the Homozygous G200SNicotinamide Nucleotide Transhydrogenase Mutation Is Surprisingly Caused by Rare Bilateral Para-Overian Adrenal Rest Tumors
por: Cahn, Ranit, et al.
Publicado: (2021)

Antisense lncRNA NNT-AS1 promoted esophageal squamous cell carcinoma progression by regulating its sense gene NNT expression
por: Pan, Xianglong, et al.
Publicado: (2022)

Molecular architecture and electron transfer pathway of the Stn family transhydrogenase
por: Kumar, Anuj, et al.
Publicado: (2023)

Long-Term Follow-Up of Three Family Members with a Novel NNT Pathogenic Variant Causing Primary Adrenal Insufficiency
por: Krasovec, Tjasa, et al.
Publicado: (2022)

Using and Interpreting Adjusted NNT Measures in Biomedical Research
por: Bender, Ralf
Publicado: (2010)

Number needed to treat (NNT) in clinical literature: an appraisal
por: Mendes, Diogo, et al.
Publicado: (2017)

LncRNA NNT-AS1 contributes to the cisplatin resistance of cervical cancer through NNT-AS1/miR-186/HMGB1 axis
por: Liu, Yanjie, et al.
Publicado: (2020)

Transhydrogenase Promotes the Robustness and Evolvability of E. coli Deficient in NADPH Production
por: Chou, Hsin-Hung, et al.
Publicado: (2015)

NAD(P) transhydrogenase isoform distribution provides insight into apicomplexan evolution
por: Tremp, Annie Z., et al.
Publicado: (2023)

Effects of 20-Hydroxyecdysone on the Reversible Mitochondrial Transhydrogenase in the Tobacco Hornworm, Manduca sexta
por: Vandock, Kurt P., et al.
Publicado: (2013)

How to Obtain NNT from Cohen's d: Comparison of Two Methods
por: Furukawa, Toshi A., et al.
Publicado: (2011)

AGeNNT: annotation of enzyme families by means of refined neighborhood networks
por: Kandlinger, Florian, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_5q2u3d2mbin0t3s33fcknia94c