Excess of Deleterious Mutations around HLA Genes Reveals Evolutionary Cost of Balancing Selection

Deleterious mutations are expected to evolve under negative selection and are usually purged from the population. However, deleterious alleles segregate in the human population and some disease-associated variants are maintained at considerable frequencies. Here, we test the hypothesis that balancin...

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Detalles Bibliográficos
Autores principales: Lenz, Tobias L., Spirin, Victor, Jordan, Daniel M., Sunyaev, Shamil R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026253/
https://www.ncbi.nlm.nih.gov/pubmed/27436009
http://dx.doi.org/10.1093/molbev/msw127

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026253/
https://www.ncbi.nlm.nih.gov/pubmed/27436009
http://dx.doi.org/10.1093/molbev/msw127

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