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Excess of Deleterious Mutations around HLA Genes Reveals Evolutionary Cost of Balancing Selection
Deleterious mutations are expected to evolve under negative selection and are usually purged from the population. However, deleterious alleles segregate in the human population and some disease-associated variants are maintained at considerable frequencies. Here, we test the hypothesis that balancin...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026253/ https://www.ncbi.nlm.nih.gov/pubmed/27436009 http://dx.doi.org/10.1093/molbev/msw127 |