Monkeypox virus induces the synthesis of less dsRNA than vaccinia virus, and is more resistant to the anti-poxvirus drug, IBT, than vaccinia virus

Monkeypox virus (MPXV) infection fails to activate the host anti-viral protein, PKR, despite lacking a full-length homologue of the vaccinia virus (VACV) PKR inhibitor, E3. Since PKR can be activated by dsRNA produced during a viral infection, we have analyzed the accumulation of dsRNA in MPXV-infec...

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Detalles Bibliográficos
Autores principales: Arndt, William D., White, Stacy D., Johnson, Brian P., Huynh, Trung, Liao, Jeffrey, Harrington, Heather, Cotsmire, Samantha, Kibler, Karen V., Langland, Jeffrey, Jacobs, Bertram L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026613/
https://www.ncbi.nlm.nih.gov/pubmed/27467578
http://dx.doi.org/10.1016/j.virol.2016.07.016

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