Lipid microdomain modification sustains neuronal viability in models of Alzheimer’s disease

Decreased neuronal insulin receptor (IR) signaling in Alzheimer’s disease is suggested to contribute to synaptic loss and neurodegeneration. This work shows that alteration of membrane microdomains increases IR levels and signaling, as well as neuronal viability in AD models in vitro and in vivo. Ne...

Descripción completa

Detalles Bibliográficos
Autores principales: Herzer, Silke, Meldner, Sascha, Rehder, Klara, Gröne, Hermann-Josef, Nordström, Viola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027102/
https://www.ncbi.nlm.nih.gov/pubmed/27639375
http://dx.doi.org/10.1186/s40478-016-0354-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027102/
https://www.ncbi.nlm.nih.gov/pubmed/27639375
http://dx.doi.org/10.1186/s40478-016-0354-z

Ejemplares similares