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Efficient generation and reversion of chromosomal translocations using CRISPR/Cas technology

BACKGROUND: Chromosomal translocations are a hallmark of cancer cells and give rise to fusion oncogenes. To gain insight into the mechanisms governing tumorigenesis, adequate model cell lines are required. RESULTS: We employ the versatile CRISPR/Cas system to engineer cell lines in which chromosomal...

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Detalles Bibliográficos
Autores principales:	Lekomtsev, Sergey, Aligianni, Sofia, Lapao, Ana, Bürckstümmer, Tilmann
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027121/ https://www.ncbi.nlm.nih.gov/pubmed/27640184 http://dx.doi.org/10.1186/s12864-016-3084-5

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