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Central relay of bitter taste to the protocerebrum by peptidergic interneurons in the Drosophila brain
Bitter is a taste modality associated with toxic substances evoking aversive behaviour in most animals, and the valence of different taste modalities is conserved between mammals and Drosophila. Despite knowledge gathered in the past on the peripheral perception of taste, little is known about the i...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027282/ https://www.ncbi.nlm.nih.gov/pubmed/27619503 http://dx.doi.org/10.1038/ncomms12796 |
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author | Hückesfeld, Sebastian Peters, Marc Pankratz, Michael J. |
author_facet | Hückesfeld, Sebastian Peters, Marc Pankratz, Michael J. |
author_sort | Hückesfeld, Sebastian |
collection | PubMed |
description | Bitter is a taste modality associated with toxic substances evoking aversive behaviour in most animals, and the valence of different taste modalities is conserved between mammals and Drosophila. Despite knowledge gathered in the past on the peripheral perception of taste, little is known about the identity of taste interneurons in the brain. Here we show that hugin neuropeptide-containing neurons in the Drosophila larval brain are necessary for avoidance behaviour to caffeine, and when activated, result in cessation of feeding and mediates a bitter taste signal within the brain. Hugin neuropeptide-containing neurons project to the neurosecretory region of the protocerebrum and functional imaging demonstrates that these neurons are activated by bitter stimuli and by activation of bitter sensory receptor neurons. We propose that hugin neurons projecting to the protocerebrum act as gustatory interneurons relaying bitter taste information to higher brain centres in Drosophila larvae. |
format | Online Article Text |
id | pubmed-5027282 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-50272822016-09-23 Central relay of bitter taste to the protocerebrum by peptidergic interneurons in the Drosophila brain Hückesfeld, Sebastian Peters, Marc Pankratz, Michael J. Nat Commun Article Bitter is a taste modality associated with toxic substances evoking aversive behaviour in most animals, and the valence of different taste modalities is conserved between mammals and Drosophila. Despite knowledge gathered in the past on the peripheral perception of taste, little is known about the identity of taste interneurons in the brain. Here we show that hugin neuropeptide-containing neurons in the Drosophila larval brain are necessary for avoidance behaviour to caffeine, and when activated, result in cessation of feeding and mediates a bitter taste signal within the brain. Hugin neuropeptide-containing neurons project to the neurosecretory region of the protocerebrum and functional imaging demonstrates that these neurons are activated by bitter stimuli and by activation of bitter sensory receptor neurons. We propose that hugin neurons projecting to the protocerebrum act as gustatory interneurons relaying bitter taste information to higher brain centres in Drosophila larvae. Nature Publishing Group 2016-09-13 /pmc/articles/PMC5027282/ /pubmed/27619503 http://dx.doi.org/10.1038/ncomms12796 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Hückesfeld, Sebastian Peters, Marc Pankratz, Michael J. Central relay of bitter taste to the protocerebrum by peptidergic interneurons in the Drosophila brain |
title | Central relay of bitter taste to the protocerebrum by peptidergic interneurons in the Drosophila brain |
title_full | Central relay of bitter taste to the protocerebrum by peptidergic interneurons in the Drosophila brain |
title_fullStr | Central relay of bitter taste to the protocerebrum by peptidergic interneurons in the Drosophila brain |
title_full_unstemmed | Central relay of bitter taste to the protocerebrum by peptidergic interneurons in the Drosophila brain |
title_short | Central relay of bitter taste to the protocerebrum by peptidergic interneurons in the Drosophila brain |
title_sort | central relay of bitter taste to the protocerebrum by peptidergic interneurons in the drosophila brain |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027282/ https://www.ncbi.nlm.nih.gov/pubmed/27619503 http://dx.doi.org/10.1038/ncomms12796 |
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