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Central relay of bitter taste to the protocerebrum by peptidergic interneurons in the Drosophila brain

Bitter is a taste modality associated with toxic substances evoking aversive behaviour in most animals, and the valence of different taste modalities is conserved between mammals and Drosophila. Despite knowledge gathered in the past on the peripheral perception of taste, little is known about the i...

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Autores principales: Hückesfeld, Sebastian, Peters, Marc, Pankratz, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027282/
https://www.ncbi.nlm.nih.gov/pubmed/27619503
http://dx.doi.org/10.1038/ncomms12796
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author Hückesfeld, Sebastian
Peters, Marc
Pankratz, Michael J.
author_facet Hückesfeld, Sebastian
Peters, Marc
Pankratz, Michael J.
author_sort Hückesfeld, Sebastian
collection PubMed
description Bitter is a taste modality associated with toxic substances evoking aversive behaviour in most animals, and the valence of different taste modalities is conserved between mammals and Drosophila. Despite knowledge gathered in the past on the peripheral perception of taste, little is known about the identity of taste interneurons in the brain. Here we show that hugin neuropeptide-containing neurons in the Drosophila larval brain are necessary for avoidance behaviour to caffeine, and when activated, result in cessation of feeding and mediates a bitter taste signal within the brain. Hugin neuropeptide-containing neurons project to the neurosecretory region of the protocerebrum and functional imaging demonstrates that these neurons are activated by bitter stimuli and by activation of bitter sensory receptor neurons. We propose that hugin neurons projecting to the protocerebrum act as gustatory interneurons relaying bitter taste information to higher brain centres in Drosophila larvae.
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spelling pubmed-50272822016-09-23 Central relay of bitter taste to the protocerebrum by peptidergic interneurons in the Drosophila brain Hückesfeld, Sebastian Peters, Marc Pankratz, Michael J. Nat Commun Article Bitter is a taste modality associated with toxic substances evoking aversive behaviour in most animals, and the valence of different taste modalities is conserved between mammals and Drosophila. Despite knowledge gathered in the past on the peripheral perception of taste, little is known about the identity of taste interneurons in the brain. Here we show that hugin neuropeptide-containing neurons in the Drosophila larval brain are necessary for avoidance behaviour to caffeine, and when activated, result in cessation of feeding and mediates a bitter taste signal within the brain. Hugin neuropeptide-containing neurons project to the neurosecretory region of the protocerebrum and functional imaging demonstrates that these neurons are activated by bitter stimuli and by activation of bitter sensory receptor neurons. We propose that hugin neurons projecting to the protocerebrum act as gustatory interneurons relaying bitter taste information to higher brain centres in Drosophila larvae. Nature Publishing Group 2016-09-13 /pmc/articles/PMC5027282/ /pubmed/27619503 http://dx.doi.org/10.1038/ncomms12796 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Hückesfeld, Sebastian
Peters, Marc
Pankratz, Michael J.
Central relay of bitter taste to the protocerebrum by peptidergic interneurons in the Drosophila brain
title Central relay of bitter taste to the protocerebrum by peptidergic interneurons in the Drosophila brain
title_full Central relay of bitter taste to the protocerebrum by peptidergic interneurons in the Drosophila brain
title_fullStr Central relay of bitter taste to the protocerebrum by peptidergic interneurons in the Drosophila brain
title_full_unstemmed Central relay of bitter taste to the protocerebrum by peptidergic interneurons in the Drosophila brain
title_short Central relay of bitter taste to the protocerebrum by peptidergic interneurons in the Drosophila brain
title_sort central relay of bitter taste to the protocerebrum by peptidergic interneurons in the drosophila brain
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027282/
https://www.ncbi.nlm.nih.gov/pubmed/27619503
http://dx.doi.org/10.1038/ncomms12796
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