Key Challenges and Opportunities Associated with the Use of In Vitro Models to Detect Human DILI: Integrated Risk Assessment and Mitigation Plans

Drug-induced liver injury (DILI) is a major cause of late-stage clinical drug attrition, market withdrawal, black-box warnings, and acute liver failure. Consequently, it has been an area of focus for toxicologists and clinicians for several decades. In spite of considerable efforts, limited improvem...

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Detalles Bibliográficos
Autores principales: Atienzar, Franck A., Blomme, Eric A., Chen, Minjun, Hewitt, Philip, Kenna, J. Gerry, Labbe, Gilles, Moulin, Frederic, Pognan, Francois, Roth, Adrian B., Suter-Dick, Laura, Ukairo, Okechukwu, Weaver, Richard J., Will, Yvonne, Dambach, Donna M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027328/
https://www.ncbi.nlm.nih.gov/pubmed/27689095
http://dx.doi.org/10.1155/2016/9737920

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