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Profiling of 2′-O-Me in human rRNA reveals a subset of fractionally modified positions and provides evidence for ribosome heterogeneity

Ribose methylation is one of the two most abundant modifications in human ribosomal RNA and is believed to be important for ribosome biogenesis, mRNA selectivity and translational fidelity. We have applied RiboMeth-seq to rRNA from HeLa cells for ribosome-wide, quantitative mapping of 2′-O-Me sites...

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Detalles Bibliográficos
Autores principales:	Krogh, Nicolai, Jansson, Martin D., Häfner, Sophia J., Tehler, Disa, Birkedal, Ulf, Christensen-Dalsgaard, Mikkel, Lund, Anders H., Nielsen, Henrik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	RNA
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027482/ https://www.ncbi.nlm.nih.gov/pubmed/27257078 http://dx.doi.org/10.1093/nar/gkw482

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