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A defect in homologous recombination leads to increased translesion synthesis in E. coli

DNA damage tolerance pathways allow cells to duplicate their genomes despite the presence of replication blocking lesions. Cells possess two major tolerance strategies, namely translesion synthesis (TLS) and homology directed gap repair (HDGR). TLS pathways involve specialized DNA polymerases that a...

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Detalles Bibliográficos
Autores principales:	Naiman, Karel, Pagès, Vincent, Fuchs, Robert P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027485/ https://www.ncbi.nlm.nih.gov/pubmed/27257075 http://dx.doi.org/10.1093/nar/gkw488

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