Triplex structures induce DNA double strand breaks via replication fork collapse in NER deficient cells

Structural alterations in DNA can serve as natural impediments to replication fork stability and progression, resulting in DNA damage and genomic instability. Naturally occurring polypurine mirror repeat sequences in the human genome can create endogenous triplex structures evoking a robust DNA dama...

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Detalles Bibliográficos
Autores principales: Kaushik Tiwari, Meetu, Adaku, Nneoma, Peart, Natoya, Rogers, Faye A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027492/
https://www.ncbi.nlm.nih.gov/pubmed/27298253
http://dx.doi.org/10.1093/nar/gkw515

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027492/
https://www.ncbi.nlm.nih.gov/pubmed/27298253
http://dx.doi.org/10.1093/nar/gkw515

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