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Length heterogeneity at conserved sequence block 2 in human mitochondrial DNA acts as a rheostat for RNA polymerase POLRMT activity

The guanine (G)-tract of conserved sequence block 2 (CSB 2) in human mitochondrial DNA can result in transcription termination due to formation of a hybrid G-quadruplex between the nascent RNA and the nontemplate DNA strand. This structure can then influence genome replication, stability and localiz...

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Detalles Bibliográficos
Autores principales:	Tan, Benedict G., Wellesley, Frederick C., Savery, Nigel J., Szczelkun, Mark D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027508/ https://www.ncbi.nlm.nih.gov/pubmed/27436287 http://dx.doi.org/10.1093/nar/gkw648

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