Dopaminergic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects

Some mutations of the LRRK2 gene underlie autosomal dominant form of Parkinson’s disease (PD). The G2019S is a common mutation that accounts for about 2% of PD cases. To understand the pathophysiology of this mutation and its possible developmental implications, we developed an in vitro assay to mod...

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Detalles Bibliográficos
Autores principales: Borgs, Laurence, Peyre, Elise, Alix, Philippe, Hanon, Kevin, Grobarczyk, Benjamin, Godin, Juliette D., Purnelle, Audrey, Krusy, Nathalie, Maquet, Pierre, Lefebvre, Philippe, Seutin, Vincent, Malgrange, Brigitte, Nguyen, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027571/
https://www.ncbi.nlm.nih.gov/pubmed/27640816
http://dx.doi.org/10.1038/srep33377

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