Cargando…

Flexible Neural Electrode Array Based-on Porous Graphene for Cortical Microstimulation and Sensing

Neural sensing and stimulation have been the backbone of neuroscience research, brain-machine interfaces and clinical neuromodulation therapies for decades. To-date, most of the neural stimulation systems have relied on sharp metal microelectrodes with poor electrochemical properties that induce ext...

Descripción completa

Detalles Bibliográficos
Autores principales: Lu, Yichen, Lyu, Hongming, Richardson, Andrew G., Lucas, Timothy H., Kuzum, Duygu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027596/
https://www.ncbi.nlm.nih.gov/pubmed/27642117
http://dx.doi.org/10.1038/srep33526
_version_ 1782454268636168192
author Lu, Yichen
Lyu, Hongming
Richardson, Andrew G.
Lucas, Timothy H.
Kuzum, Duygu
author_facet Lu, Yichen
Lyu, Hongming
Richardson, Andrew G.
Lucas, Timothy H.
Kuzum, Duygu
author_sort Lu, Yichen
collection PubMed
description Neural sensing and stimulation have been the backbone of neuroscience research, brain-machine interfaces and clinical neuromodulation therapies for decades. To-date, most of the neural stimulation systems have relied on sharp metal microelectrodes with poor electrochemical properties that induce extensive damage to the tissue and significantly degrade the long-term stability of implantable systems. Here, we demonstrate a flexible cortical microelectrode array based on porous graphene, which is capable of efficient electrophysiological sensing and stimulation from the brain surface, without penetrating into the tissue. Porous graphene electrodes show superior impedance and charge injection characteristics making them ideal for high efficiency cortical sensing and stimulation. They exhibit no physical delamination or degradation even after 1 million biphasic stimulation cycles, confirming high endurance. In in vivo experiments with rodents, same array is used to sense brain activity patterns with high spatio-temporal resolution and to control leg muscles with high-precision electrical stimulation from the cortical surface. Flexible porous graphene array offers a minimally invasive but high efficiency neuromodulation scheme with potential applications in cortical mapping, brain-computer interfaces, treatment of neurological disorders, where high resolution and simultaneous recording and stimulation of neural activity are crucial.
format Online
Article
Text
id pubmed-5027596
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-50275962016-09-22 Flexible Neural Electrode Array Based-on Porous Graphene for Cortical Microstimulation and Sensing Lu, Yichen Lyu, Hongming Richardson, Andrew G. Lucas, Timothy H. Kuzum, Duygu Sci Rep Article Neural sensing and stimulation have been the backbone of neuroscience research, brain-machine interfaces and clinical neuromodulation therapies for decades. To-date, most of the neural stimulation systems have relied on sharp metal microelectrodes with poor electrochemical properties that induce extensive damage to the tissue and significantly degrade the long-term stability of implantable systems. Here, we demonstrate a flexible cortical microelectrode array based on porous graphene, which is capable of efficient electrophysiological sensing and stimulation from the brain surface, without penetrating into the tissue. Porous graphene electrodes show superior impedance and charge injection characteristics making them ideal for high efficiency cortical sensing and stimulation. They exhibit no physical delamination or degradation even after 1 million biphasic stimulation cycles, confirming high endurance. In in vivo experiments with rodents, same array is used to sense brain activity patterns with high spatio-temporal resolution and to control leg muscles with high-precision electrical stimulation from the cortical surface. Flexible porous graphene array offers a minimally invasive but high efficiency neuromodulation scheme with potential applications in cortical mapping, brain-computer interfaces, treatment of neurological disorders, where high resolution and simultaneous recording and stimulation of neural activity are crucial. Nature Publishing Group 2016-09-19 /pmc/articles/PMC5027596/ /pubmed/27642117 http://dx.doi.org/10.1038/srep33526 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Lu, Yichen
Lyu, Hongming
Richardson, Andrew G.
Lucas, Timothy H.
Kuzum, Duygu
Flexible Neural Electrode Array Based-on Porous Graphene for Cortical Microstimulation and Sensing
title Flexible Neural Electrode Array Based-on Porous Graphene for Cortical Microstimulation and Sensing
title_full Flexible Neural Electrode Array Based-on Porous Graphene for Cortical Microstimulation and Sensing
title_fullStr Flexible Neural Electrode Array Based-on Porous Graphene for Cortical Microstimulation and Sensing
title_full_unstemmed Flexible Neural Electrode Array Based-on Porous Graphene for Cortical Microstimulation and Sensing
title_short Flexible Neural Electrode Array Based-on Porous Graphene for Cortical Microstimulation and Sensing
title_sort flexible neural electrode array based-on porous graphene for cortical microstimulation and sensing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027596/
https://www.ncbi.nlm.nih.gov/pubmed/27642117
http://dx.doi.org/10.1038/srep33526
work_keys_str_mv AT luyichen flexibleneuralelectrodearraybasedonporousgrapheneforcorticalmicrostimulationandsensing
AT lyuhongming flexibleneuralelectrodearraybasedonporousgrapheneforcorticalmicrostimulationandsensing
AT richardsonandrewg flexibleneuralelectrodearraybasedonporousgrapheneforcorticalmicrostimulationandsensing
AT lucastimothyh flexibleneuralelectrodearraybasedonporousgrapheneforcorticalmicrostimulationandsensing
AT kuzumduygu flexibleneuralelectrodearraybasedonporousgrapheneforcorticalmicrostimulationandsensing