The cytotoxic mechanisms of disulfiram and copper(ii) in cancer cells

The anticancer activity of disulfiram (DS) is copper(ii) (Cu)-dependent. This study investigated the anticancer mechanisms of DS/Cu using in vitro cytotoxicity and metabolic kinetic analysis. Our study indicates that DS/Cu targets cancer cells by the combination of two types of actions: (1) instant...

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Detalles Bibliográficos
Autores principales: Tawari, Patricia Erebi, Wang, Zhipeng, Najlah, Mohammad, Tsang, Chi Wai, Kannappan, Vinodh, Liu, Peng, McConville, Christopher, He, Bin, Armesilla, Angel L., Wang, Weiguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027600/
https://www.ncbi.nlm.nih.gov/pubmed/27708770
http://dx.doi.org/10.1039/c5tx00210a
Descripción
Sumario:The anticancer activity of disulfiram (DS) is copper(ii) (Cu)-dependent. This study investigated the anticancer mechanisms of DS/Cu using in vitro cytotoxicity and metabolic kinetic analysis. Our study indicates that DS/Cu targets cancer cells by the combination of two types of actions: (1) instant killing executed by DS/Cu reaction generated reactive oxygen species; (2) delayed cytotoxicity introduced by the end product, DDC-Cu. Nanoencapsulation of DS might shed light on repositioning of DS into cancer treatment.

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