The cytotoxic mechanisms of disulfiram and copper(ii) in cancer cells

The anticancer activity of disulfiram (DS) is copper(ii) (Cu)-dependent. This study investigated the anticancer mechanisms of DS/Cu using in vitro cytotoxicity and metabolic kinetic analysis. Our study indicates that DS/Cu targets cancer cells by the combination of two types of actions: (1) instant...

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Autores principales: Tawari, Patricia Erebi, Wang, Zhipeng, Najlah, Mohammad, Tsang, Chi Wai, Kannappan, Vinodh, Liu, Peng, McConville, Christopher, He, Bin, Armesilla, Angel L., Wang, Weiguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027600/
https://www.ncbi.nlm.nih.gov/pubmed/27708770
http://dx.doi.org/10.1039/c5tx00210a
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author Tawari, Patricia Erebi
Wang, Zhipeng
Najlah, Mohammad
Tsang, Chi Wai
Kannappan, Vinodh
Liu, Peng
McConville, Christopher
He, Bin
Armesilla, Angel L.
Wang, Weiguang
author_facet Tawari, Patricia Erebi
Wang, Zhipeng
Najlah, Mohammad
Tsang, Chi Wai
Kannappan, Vinodh
Liu, Peng
McConville, Christopher
He, Bin
Armesilla, Angel L.
Wang, Weiguang
author_sort Tawari, Patricia Erebi
collection PubMed
description The anticancer activity of disulfiram (DS) is copper(ii) (Cu)-dependent. This study investigated the anticancer mechanisms of DS/Cu using in vitro cytotoxicity and metabolic kinetic analysis. Our study indicates that DS/Cu targets cancer cells by the combination of two types of actions: (1) instant killing executed by DS/Cu reaction generated reactive oxygen species; (2) delayed cytotoxicity introduced by the end product, DDC-Cu. Nanoencapsulation of DS might shed light on repositioning of DS into cancer treatment.
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spelling pubmed-50276002016-10-03 The cytotoxic mechanisms of disulfiram and copper(ii) in cancer cells Tawari, Patricia Erebi Wang, Zhipeng Najlah, Mohammad Tsang, Chi Wai Kannappan, Vinodh Liu, Peng McConville, Christopher He, Bin Armesilla, Angel L. Wang, Weiguang Toxicol Res (Camb) Chemistry The anticancer activity of disulfiram (DS) is copper(ii) (Cu)-dependent. This study investigated the anticancer mechanisms of DS/Cu using in vitro cytotoxicity and metabolic kinetic analysis. Our study indicates that DS/Cu targets cancer cells by the combination of two types of actions: (1) instant killing executed by DS/Cu reaction generated reactive oxygen species; (2) delayed cytotoxicity introduced by the end product, DDC-Cu. Nanoencapsulation of DS might shed light on repositioning of DS into cancer treatment. Royal Society of Chemistry 2015-11-19 2015-09-10 /pmc/articles/PMC5027600/ /pubmed/27708770 http://dx.doi.org/10.1039/c5tx00210a Text en This journal is © The Royal Society of Chemistry 2015 http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Tawari, Patricia Erebi
Wang, Zhipeng
Najlah, Mohammad
Tsang, Chi Wai
Kannappan, Vinodh
Liu, Peng
McConville, Christopher
He, Bin
Armesilla, Angel L.
Wang, Weiguang
The cytotoxic mechanisms of disulfiram and copper(ii) in cancer cells
title The cytotoxic mechanisms of disulfiram and copper(ii) in cancer cells
title_full The cytotoxic mechanisms of disulfiram and copper(ii) in cancer cells
title_fullStr The cytotoxic mechanisms of disulfiram and copper(ii) in cancer cells
title_full_unstemmed The cytotoxic mechanisms of disulfiram and copper(ii) in cancer cells
title_short The cytotoxic mechanisms of disulfiram and copper(ii) in cancer cells
title_sort cytotoxic mechanisms of disulfiram and copper(ii) in cancer cells
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027600/
https://www.ncbi.nlm.nih.gov/pubmed/27708770
http://dx.doi.org/10.1039/c5tx00210a
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