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MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C
Cirrhosis likely shares common pathophysiological pathways despite arising from a variety of liver diseases. A recent GWAS identified rs641738, a polymorphism in the MBOAT7 locus, as being associated with the development of alcoholic cirrhosis. Here we explore the role of this variant on liver infla...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027609/ https://www.ncbi.nlm.nih.gov/pubmed/27630043 http://dx.doi.org/10.1038/ncomms12757 |
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author | Thabet, Khaled Asimakopoulos, Anastasia Shojaei, Maryam Romero-Gomez, Manuel Mangia, Alessandra Irving, William L. Berg, Thomas Dore, Gregory J. Grønbæk, Henning Sheridan, David Abate, Maria Lorena Bugianesi, Elisabetta Weltman, Martin Mollison, Lindsay Cheng, Wendy Riordan, Stephen Fischer, Janett Spengler, Ulrich Nattermann, Jacob Wahid, Ahmed Rojas, Angela White, Rose Douglas, Mark W. McLeod, Duncan Powell, Elizabeth Liddle, Christopher van der Poorten, David George, Jacob Eslam, Mohammed |
author_facet | Thabet, Khaled Asimakopoulos, Anastasia Shojaei, Maryam Romero-Gomez, Manuel Mangia, Alessandra Irving, William L. Berg, Thomas Dore, Gregory J. Grønbæk, Henning Sheridan, David Abate, Maria Lorena Bugianesi, Elisabetta Weltman, Martin Mollison, Lindsay Cheng, Wendy Riordan, Stephen Fischer, Janett Spengler, Ulrich Nattermann, Jacob Wahid, Ahmed Rojas, Angela White, Rose Douglas, Mark W. McLeod, Duncan Powell, Elizabeth Liddle, Christopher van der Poorten, David George, Jacob Eslam, Mohammed |
author_sort | Thabet, Khaled |
collection | PubMed |
description | Cirrhosis likely shares common pathophysiological pathways despite arising from a variety of liver diseases. A recent GWAS identified rs641738, a polymorphism in the MBOAT7 locus, as being associated with the development of alcoholic cirrhosis. Here we explore the role of this variant on liver inflammation and fibrosis in two cohorts of patients with chronic hepatitis C. In 2,051 patients, rs641738 associated with severe hepatic inflammation and increased risk of fibrosis, as well as fast fibrosis progression. At functional level, rs641738 associated with MBOAT7 transcript and protein levels in liver and blood, and with serum inflammatory, oxidative stress and macrophage activation markers. MBOAT7 was expressed in immune cell subsets, implying a role in hepatic inflammation. We conclude that the MBOAT7 rs641738 polymorphism is a novel risk variant for liver inflammation in hepatitis C, and thereby for liver fibrosis. |
format | Online Article Text |
id | pubmed-5027609 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-50276092016-09-23 MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C Thabet, Khaled Asimakopoulos, Anastasia Shojaei, Maryam Romero-Gomez, Manuel Mangia, Alessandra Irving, William L. Berg, Thomas Dore, Gregory J. Grønbæk, Henning Sheridan, David Abate, Maria Lorena Bugianesi, Elisabetta Weltman, Martin Mollison, Lindsay Cheng, Wendy Riordan, Stephen Fischer, Janett Spengler, Ulrich Nattermann, Jacob Wahid, Ahmed Rojas, Angela White, Rose Douglas, Mark W. McLeod, Duncan Powell, Elizabeth Liddle, Christopher van der Poorten, David George, Jacob Eslam, Mohammed Nat Commun Article Cirrhosis likely shares common pathophysiological pathways despite arising from a variety of liver diseases. A recent GWAS identified rs641738, a polymorphism in the MBOAT7 locus, as being associated with the development of alcoholic cirrhosis. Here we explore the role of this variant on liver inflammation and fibrosis in two cohorts of patients with chronic hepatitis C. In 2,051 patients, rs641738 associated with severe hepatic inflammation and increased risk of fibrosis, as well as fast fibrosis progression. At functional level, rs641738 associated with MBOAT7 transcript and protein levels in liver and blood, and with serum inflammatory, oxidative stress and macrophage activation markers. MBOAT7 was expressed in immune cell subsets, implying a role in hepatic inflammation. We conclude that the MBOAT7 rs641738 polymorphism is a novel risk variant for liver inflammation in hepatitis C, and thereby for liver fibrosis. Nature Publishing Group 2016-09-15 /pmc/articles/PMC5027609/ /pubmed/27630043 http://dx.doi.org/10.1038/ncomms12757 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Thabet, Khaled Asimakopoulos, Anastasia Shojaei, Maryam Romero-Gomez, Manuel Mangia, Alessandra Irving, William L. Berg, Thomas Dore, Gregory J. Grønbæk, Henning Sheridan, David Abate, Maria Lorena Bugianesi, Elisabetta Weltman, Martin Mollison, Lindsay Cheng, Wendy Riordan, Stephen Fischer, Janett Spengler, Ulrich Nattermann, Jacob Wahid, Ahmed Rojas, Angela White, Rose Douglas, Mark W. McLeod, Duncan Powell, Elizabeth Liddle, Christopher van der Poorten, David George, Jacob Eslam, Mohammed MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C |
title | MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C |
title_full | MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C |
title_fullStr | MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C |
title_full_unstemmed | MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C |
title_short | MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C |
title_sort | mboat7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis c |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027609/ https://www.ncbi.nlm.nih.gov/pubmed/27630043 http://dx.doi.org/10.1038/ncomms12757 |
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